Determination of Naproxine in its pure form and in some Pharmaceuticals by vis-Spectrophotometry using the Chrome Azrol S

Authors

  • Malek Okdeh
  • Juhaina Dib
  • Mohammad Obeid

Abstract

This study shows the possibility of determining the (NAP) in its pure state and in Pharmaceuticals using Chrome Azrol S Reagent . This spectral method was based on the formation of a colored violet complex at pH=3.5 , The complex has a maximum absorbance value at a wavelength of 545nm. The relationship between absorbance and naproxine concentrations was linear. The Beer-Lambert’s law is within the range of concentrations between (2.306-46.047) µg/ml and with a Relative  percentage  standard deviation of 1.288 and with a correlation coefficient of  R2=0.9987 and a molar absorption coefficient of (1.15×104( L.mol-1.cm-1.The detection limit of naproxen was 0.5873, and the results indicated that the presence of adjuvants does not affect the determination process of naproxen. The analytical results were characterized by a good selectivity, accuracy and sensitivity to the identification of some active substances in  its pure state and pharmaceuticals, at a lower cost than the approved constitutional methods

 

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Published

2019-09-09

How to Cite

1.
Okdeh M, Dib J, Obeid M. Determination of Naproxine in its pure form and in some Pharmaceuticals by vis-Spectrophotometry using the Chrome Azrol S. TUJ-BA [Internet]. 2019Sep.9 [cited 2024Apr.24];41(4). Available from: https://journal.tishreen.edu.sy/index.php/bassnc/article/view/9002

Issue

Vol. 41 No. 4 (2019): العلوم الأساسية

Section

Articles

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