The Effect Of Soybean Seeds Extract On Hyperthyroidism Which Induced In White Mice

Authors

  • Hiam Kamel Fadel
  • Ghada Rafik Hassan

Abstract

This study aimed to determine the effect of aqueous soybean seeds extract on the levels of FT3 and FT4 in the blood serum of induced hyperthyroidism white adult mice and promoting  it’s therapeutic capacity. This study, included 40 Female white mice,( Balb/c strain), which were divided into four experimental groups (10 mice in each). The first group (the physiological control), was treated with oral cavity of 0.9% Nacl until the end of the experiment, while the second group (the pathological control) ,was treated  with oral cavity  of LT4 in adose 100µg/100g for 10 day whereas The third and fourth groups (treatment groups), were treated with oral cavity of 100 and 300mg/Kg aqueous extract of soybean for 4 weeks. At the end of the experiment, the treated animals were anesthetized, and the blood samples were drawn by Cardiac puncture. Results showed that the aqueous extract of soybean seeds has a positive effect on hyperthyroidism, as the levels of FT3-FT4 were significantly decreased (P<0.05) by  it’s effect.

 

هدفت هذه الدراسة الى تحديد تأثير مستخلص بذور فول الصويا المائي في مستوياتFT4 ,FT3 في مصل دم الفئران البيضاء البالغة المستحدث فيها فرط الدرق و تسليط الضوء على فعاليته العلاجية .

شملت الدراسة  40من اناث الفئران البيضاء من سلالة Balb/c والتي وزعت على أربع مجموعات تجريبية  10)فئران في كل مجموعة), كانت المجموعة الأولى الشاهدة الفيزيولوجية , تم تجريعها بمحلول فيزيولوجي  0.9Nacl% حتى نهاية التجربة, أما المجموعة الثانية فكانت الشاهدة المرضية التي جرعت بعقار ليفوتيروكسينLT4 بجرعة قدرها  100ميكروغرام/ 100غرام 10 أيام متتالية, في حين كانت المجموعتان الثالثة والرابعة: مجموعتين تجريبيتين جُرّعتا  ب 100ملغ/كغ و  300ملغ/كغ على التوالي من مستخلص بذور فول الصويا المائي مدة أربعة أسابيع متتالية بعد استحداث فرط الدرق فيهما. في نهاية فترة التجريع تم تخدير الحيوانات و سحب الدم عن طريق طعن في القلب.

أظهرت النتائج فعالية هذا المستخلص في علاج فرط الدرق والتي تناسبت طرداً مع مقدار الجرعة, فقد انخفضت مستويات FT4و FT3 انخفاضاً معنوياً (P<0.05) بتأثيره.

Downloads

Published

2019-12-10

How to Cite

Fadel, H. K., & Hassan, G. R. (2019). The Effect Of Soybean Seeds Extract On Hyperthyroidism Which Induced In White Mice. Tishreen University Journal -Biological Sciences Series, 41(6). Retrieved from https://journal.tishreen.edu.sy/index.php/bioscnc/article/view/9280

Issue

Vol. 41 No. 6 (2019): Biological Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to the Tishreen University Journal for Research and Scientific Studies - Biological Sciences Series   

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Biological Sciences Series  .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Biological Sciences Series    Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.