Evaluation of the efficacy of bevacizumab in recurrence metastatic ovarian cancer as a second-line and beyond

Authors

  • Nader Abdullah Tishreen University

Abstract

Ovarian cancer is the most common cause of cancer death in women  approximately 60% patients are diagnosed in the advanced stages III-IV .

 Primary debulking surgery  followed by a combination of platinum-Taxans-based chemotherapy is currently considered as the standard of care for advanced epithelial ovarian cancer an alternative treatment strategy is neo adjuvant chemotherapy with delayed surgery Despite all this, relapse and death occur in 70% of patients, hence the need to search for new treatment options that improve survival, including vascular epithelial growth factor (VGFR) and PARP inhibitors. Bevacizumab is an epithelial growth factor (VGFR) inhibitor that has proven effective in many Solid tumors, especially ovarian cancer

This retrospective study aims to evaluate the efficacy of bevacizumab in patients with recurrence metastatic ovarian cancer in second-line and beyond. The study included 57 patients with  recurrence metastatic  ovarian cancer after the first line of treatment (platinum + taxans) who attended the Chemotherapy and Radiotherapy Center at Tishreen University Hospital between January 2017 and September 2021. Who treated with bevacizumab at a dose of 7.5 mg/kg every three weeks in combination with weekly paclitaxel (80 mg/m² D1, D8, D15), or gemcitabine (1000 mg/m² D1, D8) or liposomal doxorubicin 40 - 50 mg/m2 D1, D28).

. The median relapse-free survival, regardless of the treatment line, was 8.5 months (2-20 months)., we found the median relapse – free survival  when using bevacizumab as a second line of treatment( 9.8) months compared to( 7.3) months in the case of using it as a third line and beyond, the median was (12.5) months in case of endometrioid adenocarcinoma compared to (8.7) months for mucinous adenocarcinoma and 7.7 months for serous adenocarcinoma, the median relapse free survival was (9.5 months) in the case grade 3 compared to (8.2) months for grade 2 and (6.6) months for grade 1 and  we found better efficacy in the case of combination with paclitaxel (9.6) months versus (8.1) months for gemcitabine and (7.6) months for doxorubicin liposomal,.

Bevacizumab has a very important efficacy in patients with recurrent metastatic ovarian cancer after first-line therapy when used early, especially in endometrioid carcinoma and in combination with paclitaxel weekly.

Author Biography

Nader Abdullah, Tishreen University

Associate Professor - Department of Oncology - Faculty of Human Medicine

Downloads

Published

2022-03-29

How to Cite

1.
عبدالله ن. Evaluation of the efficacy of bevacizumab in recurrence metastatic ovarian cancer as a second-line and beyond. Tuj-hlth [Internet]. 2022Mar.29 [cited 2024Apr.19];44(1):49-57. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/12000

Issue

Vol. 44 No. 1 (2022): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.