Predictive value of gamma globulin gap in evaluation of therapeutic response in multiple myeloma at Tishreen University Hospital

Authors

  • kenda mohammad tishreen university
  • Firas Hussein Tishreen University
  • Faisal Redwan Tishreen University

Abstract

Introduction: The current lack of a reliable, inexpensive tool to predict treatment response in newly diagnosed Multiple Myeloma (MM) patients poses an urgent need, especially in resource-limited countries. Gamma Gap (GG) represents the measured difference between serum total protein and albumin on conventional chemistry panel.

Methods: We prospectively studied 53 newly diagnosed MM patients, who were admitted to the Cancer Treatment Center in Tishreen University Hospital in Latakia between July 2019 and July 2021, in order to determine the value of GG in predicting treatment response after first-line therapy.

Results: There was a strong linear correlation between GG and M-spike at diagnosis, at midpoint, and after treatment with r:0.89, 0.91, and 0.85, respectively, and p<0.01. ΔGG and ΔM-spike after treatment were also strongly correlated at p<0.01. ΔGG% had a clear predictive value of response after first-line therapy with an OR=1.2 and p<0.001. We were able to set a cut-off value of ΔGG% at 73% that determines the optimal response after first-line therapy, with a sensitivity of 79% and a specificity of 71%.

Conclusion: GG, measured through conventional metabolic chemistry panel, can be used as a reliable and readily available tool to estimate M-spike at different points throughout treatment. It  can also help predict treatment response in patients with newly diagnosed MM.

Downloads

Published

2022-07-31

How to Cite

1.
محمد ك, حسين ف, رضوان ف. Predictive value of gamma globulin gap in evaluation of therapeutic response in multiple myeloma at Tishreen University Hospital. Tuj-hlth [Internet]. 2022Jul.31 [cited 2024Apr.20];44(3):339-51. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/12439

Issue

Vol. 44 No. 3 (2022): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)

1 2 > >>