A study of the prevalence of liver function disorders in patients with type II diabetes mellitus

Authors

  • Zeinab Saker Tishreen University
  • Ruba Salman Tishreen University

Abstract

Background: Type 2 diabetes mellitus(T2DM) represents a disorder of glucose metabolism that characterized by hyperglycemia and insulin resistance. Liver involvement in T2DM is recognized in the form of non-alcoholic fatty liver disease(NAFLD) which can range from simple steatosis to liver cirrhosis.  

Objective: The aim of this study was to determine the prevalence of liver transaminase disorders in T2DM patients, and the association with glycemic control. 

Patients and Methods: A Descriptive Observational Cross Sectional study was   conducted for the period one year (2021 –2022) at Tishreen University Hospital in Lattakia-Syria. The study included all T2DM patients older than 18 years with a duration of diagnosis disease longer than 6 months. Alanine transaminase(ALT) and Aspartate transaminase(AST) were measured for all patients with abdominal ultrasound.  

Results: The study included 189 patients with T2DM. Fatty liver disease was detected in 72 cases (38.1%) which was associated with elevated levels of ALT in 60 cases (83.3%) and AST in 24 cases (33.3%). Elevated levels of ALT were associated significantly with increasing body mass index BMI, fasting plasma glucose FPG, glycosylated hemoglobin HbA1c, total cholesterol TC, triglyceride TG, low-density lipoprotein LDL, and decreasing high density lipoprotein HDL(p<0.05).  Elevated levels of ALT were observed more frequently in patients with fatty liver disease (76.9% versus 23.1%, p:0.0001). Elevated levels of AST were associated significantly with increasing BMI, FPG, HbA1c, TC, TG, and decreasing HDL(p<0.05).  Elevated levels of AST were observed more frequently in patients with fatty liver disease (72.7% versus 27.3%, p:0.0001).         

Conclusion: The current study demonstrated presence of fatty liver disease in important percentage of T2DM patients, and elevated levels of ALT were observed more frequently, so that early diagnosis of diabetes and initiating of therapeutic intervention is considered essential to improve final outcome.    

Downloads

Published

2023-05-18

How to Cite

1.
صقر ز, ربا سلمان. A study of the prevalence of liver function disorders in patients with type II diabetes mellitus. Tuj-hlth [Internet]. 2023May18 [cited 2024Apr.16];45(2):443-54. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/14705

Issue

Vol. 45 No. 2 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.