Development analytical method for the determination of hydroxurea (Hydrea) based on the dissociation of the nickel-chromium-azrole-S complex by visible spectrophotometer.
Abstract
This research deals with a new spectrophotometric method for the determination of hydroxyurea (Hydrea) (HU), which is one of the drugs used to reduce the accompanying effects of many pathological conditions, including thalassemia, sickle cell anemia and as an inhibitor or treatment in some cancerous tumors. This research depend on the dissociation of the complex chromium Azrole-S with nickel. the optical spectrum of each of the drug and the complex nickel-chromium azrole-S and of both together, was studied, and it was found that the best wavelength in which the absorption is maximum is at 474nm and at pH = 5. It was also found that there is an inverse linear relationship between the absorbance and the concentration of hydroxyurea, and achieved within a range of concentrations (10-100) µg/mL with a correlation coefficient R2 = 0.991, and the molar absorption coefficient was . The study also showed that the rate of dissociation of the complex relative to the drug is 1:1 and the reproducibility of the method was 98.66% with a standard deviation percentage standard deviation RSD%=4.82% The method used is also characterized by its ease, simplicity and accuracy of analysis results, which can be used in the field of drug control.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to the Tishreen University Journal -Basic Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal -Basic Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal -Basic Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.