Developing a new spectrophotometric method for analyzing valsartan by forming a colored complex with the organic reagent AAN and studying its pharmaceutical applications
Abstract
This research reviews the solubility test of the pharmaceutical valsartan .where the solubility test aims to measure the ability of the drug to dissolve in various liquids, and gives an idea of the availability of the drug and the speed of its absorption in the body.a new spectrophotometric method has been developed to determine the concentration of valsartan released from tablets. It was also complexed with the organic reagent, 3,2,7-trihydroxy-4-(bis)azonaphthalene sulfonic acid (AAN), and the reagent was prepared in the laboratory in three main steps. The steps included preparing the diazonium salt from the aromatic amine, then preparing a solution of 3,6-dihydroxynaphthalene at a concentration (0.01M), and then slowly adding the diazonium salt solution to the 3,6-dihydroxynaphthalene solution (0.01M). The solution was dried in air and an amount of HCl was added to purify it. The organic compound (AAN) was complexed with valsartan and a spectroscopic scanning process of the complexation reaction product was performed. The results showed that the maximum wavelength of the complex is at (450nm). . The amount released in all studied tablets after 30 minutes from the start of the test is not less than 80% of the amount of valsartan labeled on the tablets.Therefore it is acceptable according to the British pharmacopoeia.
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