Analytical Study for the Determination of Norfloxacin in Pure and Pharmaceutical Formulations using Alizarin by Visible Spectrophotometric Method

Authors

  • Malek okdah
  • kholoud kassab

Abstract

A Simple, accurate and highly sensitive spectrophotometric method have been developed for the rapid determination of Norfloxacin (NOR) in pure form and pharmaceutical formulations. The visible spectrophotometric method was based on the formation of a Red colored complex between the norfloxacin and Alizarin(AZ) at value of pH 7.15 and λmax at 508 nm. The effects of analytical parameters on the reported system were investigated. Beer's law was obeyed in the concentration range of 6.38-95.79μg/mL, with a percentage relative standard deviation not exceed RSD= ±0.910 and the molar absorptivity coefficients was ???? =0.227×104 (L/mol.cm). Interferences of the other ingredients and excipients were not observed,limit of detection for norfloxacin was 0.67µg.ml-1 , the results showed the high accuracy and sensitivity of the developed method.

 

Downloads

Published

2018-10-28

How to Cite

1.
okdah M, kassab kholoud. Analytical Study for the Determination of Norfloxacin in Pure and Pharmaceutical Formulations using Alizarin by Visible Spectrophotometric Method. TUJ-BA [Internet]. 2018Oct.28 [cited 2024May12];40(2). Available from: https://journal.tishreen.edu.sy/index.php/bassnc/article/view/4354

Issue

Vol. 40 No. 2 (2018): العلوم الأساسية

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to the Tishreen University Journal -Basic Sciences Series  

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal -Basic Sciences Series .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal -Basic Sciences Series   Publisher

 

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.