The Relationship between Body Mass Index and Histomolecular Classification of Breast Cancer

Authors

  • Nader Abedallaa Tishreen University
  • Samer Akel Tishreen University
  • Zaina Watfa Tishreen University

Abstract

Introduction: Increased body mass index (BMI) has been associated with the risk of developing breast cancer but the association based on molecular subtype remains conflicting.

Aim: Our main objective of this research was to analyze the relation between BMI and various molecular subtypes of breast cancer stratified with patient's age.

Materials and Methods: This was a retrospective study conducted at Oncology Department. The study enrolled a total of 680 breast cancer patients (from 2012 to 2019). All patients' BMI at the time of initial diagnosis and tumor demographics were recorded. BMI was stratified into 3 groups as normal-weighted (BMI <25 kg/m2), over-weighted (BMI=25 - 29.9 kg/m2), and obese (BMI ≥ 30 kg/m2). Immunohistochemical classification of the tumors was categorized into 5 groups as follows; luminal-A, luminal-B (Her2 like), luminal-B (Her2 negative), Her2 overexpression, and triple negative. Distribution of Immunohistochemical subtypes and tumor characteristics analysis were evaluated according to the BMI groups in both age groups (≤ 50 years and > 50 years).

Results: Mean BMI of patients ≤ 50 years and patients > 50 years was 27.05 (kg/m2) and 30.06 (kg/m2), respectively (P < 0.0001). Patients > 50 years were more obese at diagnosis (P < 0.0001).

Triple-negative subtype was significantly more frequent in obese patients ≤ 50 years compared to other subtypes (P = 0.049). Additionally, obese patients ≤ 50 years had less common luminal-A subtype (P = 0.024).

Conclusion: Our data indicated that there is an association between BMI and breast cancer indicating a decreased incidence for luminal-A subtype and increased incidence for triple negative subtype among obese patients ≤ 50 years. However, this significance was not found in patients > 50 years.

Author Biographies

Nader Abedallaa, Tishreen University

Associate Professor, Department of Oncology, Faculty of Medicine

Samer Akel, Tishreen University

Assistant Professor, Department of Oncology, Faculty of Medicine

Zaina Watfa, Tishreen University

Postgraduate Student, Department of Oncology, Faculty of Medicine

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Published

2020-11-13

How to Cite

1.
عبدالله ن, عاقل س, وطفه ز. The Relationship between Body Mass Index and Histomolecular Classification of Breast Cancer. Tuj-hlth [Internet]. 2020Nov.13 [cited 2024Nov.24];42(5). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10089

Issue

Vol. 42 No. 5 (2020): Tishreen University Journal for Research and Scientific Studies - Medical Sciences Series

Section

Articles

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