The Role of Intramuscular Progesterone in the Prevention of Preterm Labor
Abstract
Introduction: Premature birth before 37 weeks gestation is the leading cause of neonatal morbidity and mortality worldwide. Intramuscular progesterone administration has been considered effective in preventing preterm labor in high-risk women, especially with a previous PTB history and a short cervix in the middle trimester of pregnancy.
Materials and Methods: The study included 50 pregnant patients between the week (20-24 W) divided into two groups: 23 patients given intramuscular progesterone at a dose of 250 mg weekly, 27 patients not taking intramuscular progesterone. Pregnant women were evaluated through an ultra sound to determine the number of fetuses, gestational age and fetal vitality and the amount of amniotic fluid and the length of the cervix were performed hemoglobin tests, liver enzymes, urine test and sediment analysis.
Results: The percentage of the group exposed to intramuscular progesterone was 46% and for the control group 54%. The calculation of the relative risk of preterm birth was carried out in case of a previous preterm birth history and it was 0.76 and therefore lower in the exposure group compared to the control group. The effect of cervical length on the incidence of preterm labor in the exposure group was 100% if the cervical length was< 25 mm and 57.14% with cervical length 25-35 mm and 0% if it was >35mm.
Conclusion: administration of intramuscular progesterone to prevent preterm labor in high-risk women a history of a previous spontaneous preterm birth with a cervical length >35 mm.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.