The Association of Tissue transglutaminase antibody titer with duodenal histological changes in children with celiac disease in Tishreen Hospital 2018-2019
Abstract
Background: Celiac disease (CD) is one of the most common autoimmune digestive disorders in children which prevelance has recently increased in our society.
Objective: This study aims to assess the correlation between the titers of tissue anti-transglutaminase IgA (anti-tTG-IgA) antibodies and the degree of histologic changes in duodenal biopsy in children with celiac disease who admitted to Tishreen University Hospital in Lattakia during the period between (2018-2019).
Materials and Methods: A cross-sectional analytic study was conducted on 50 children who admitted to the paediatrics department at Tishreen University Hospital in Lattakia during the period from April 2018 to March 2019 and were diagnosed with celiac disease by performing an esophagogastroduodenoscopy and taking biopsies from the duodenum and studying the degree of histologic changes. According to the March classification results, a serological titration was performed for their transglutaminase (anti tTG - IgA) antibodies,and serological titration of Total IgA was performed for their negative t transglutaminase antibodies to dectect IgA deficiency .
Results : The study sample included 50 children with celiac disease , with an average age of ~ 8 years and slight preference for females. Growth failure was the most common clinical manifestations in children with 38% prevelance, followed by chronic diarrhea by 18%. The sensitivity of tissue transglutaminase antibodies ( anti-tTG-IgA) in diagnosing celiac disease reached 94%, and it was found that the value of anti tTG-IgA antibody increased with age and with increased histological changes degree of duodenal biopsies.
Conclusions: This study showed that growth failure is the most common clinical symptom of celiac disease, followed by chronic diarrhea and abdominal pain. It also confirmed the high sensitivity of transglutaminase antibodies in the diagnosis of celiac disease, and showed that the value of anti tTG-IgA antibody increased with increasing histological change degree of duodenal biopsies and with age.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.