Evaluating RBC indices in the differential diagnosis between iron deficiency anemia and beta-thalassemia trait
Abstract
Background: Anemia affects more than third of world's population and microcytic hypochromic anemia constitute an important part of anemia
Iron deficiency anemia IDA and beta thalassemia trait BTT are the most common causes of microcytic hypochromic anemia particulary in Syria
To confirm diagnosis we depend on iron studies (iron-TIBC-transferrin receptors) for IDA and hemoglobin analysis for BTT
Purpose: to evaluate the role of RBC indices and formulas in the differential diagnosis between iron deficiency anemia (IDA) and beta-thalassemia trait (BTT) by comparing them with the gold standards of diagnosis.
Methods: This study included 110 outpatients and with hypochromic microcytic anemia according to their complete blood count, all of them underwent the following blood tests: CRP-Ferritin- Hb A2 measurement by hemoglobin electrophoresis\HPLC, and then distributed into 2 groups: 50 patients with iron deficiency anemia, 50 patients with beta thalassemia trait. Ten patients were found to have both IDA and BTT. The study took place in the central laboratory at Tishreen University Hospital in Latakia, between June 2020 and February 2021.
Results: Jayabose was the best discriminant index according to Youden index that is based on sensitivity and specificity (sensitivity+specificity-100)
England and Fraser and Srivastava was the best index for diagnosis of IDA and Ricerca was the best index for diagnosis of BTT
The best cut-off of jayabose was found to be at the point 224 by using Receiver Operation Characteristic (ROC Curve)
Conclusion: according to Youden index, the most important index to discriminate between iron deficiency anemia and beta thalassemia trait was jayabose, and its cut-off is at the point 224
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.