Qualitative and quantitative study of hydroquinon in some skin whitening products available in local market

Authors

  • Ayat Abboud Tishreen University
  • Rasha Hakim Tishreen University

Abstract

Hydroquinone is one of the most effective skin lighteners in treating pigmentation. The FDA and the European Union allow to be used in pharmaceutical creams at concentrations of 2-4%, while its presence in creams that lighten the skin is prohibited due to its carcinogenic effects. This study aimed to  qualitative and quantitative determination of hydroquinone in cosmetic whitening creams. Quantitative investigation was carried out using colorimetric methods, thin layer chromatography, and UV/visible spectroscopy. UV-Visible spectroscopy was also used for quantitative purposes. The method was  firstly validated, and then applied to the studied samples. The results of   hydroquinone quantitative determination in the studied skin whitening creams showed the presence of hydroquinone in 6 types of its three patches, although the manufacturers of the six preparations did not indicate the presence of hydroquinone. Its concentration in two preparations were less than 2%, and in two preparations between 2 and 4%, while its concentration in the two preparations exceeded 4%.                                         

Author Biographies

Ayat Abboud, Tishreen University

Associate Professor, Pharmaceutical chemistry and drug quality control Department, Faculty of Pharmacy

Rasha Hakim, Tishreen University

Master Student,  Pharmaceutical chemistry and drug quality control , Faculty of Pharmacy

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Published

2021-09-16

How to Cite

1.
عبود آ, حكيم ر. Qualitative and quantitative study of hydroquinon in some skin whitening products available in local market. Tuj-hlth [Internet]. 2021Sep.16 [cited 2024Nov.24];43(4). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10906

Issue

Vol. 43 No. 4 (2021): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Articles

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