Efficacy of photodynamic therapy in the treatment of Pseudomembranous oral candidiasis
Abstract
Background: Photodynamic therapy (PDT) using methylene blue (MB) has been shown to be an effective method for the in vitro and in vivo inactivation of Candida species, however, there are limited reports of clinical investigations. The aim of this study was to explore the clinical application of PDT with MB for the treatment of oral infection caused by C. albicans in patients undergoing chemotherapy.
Methods: A total of 10 adult patients with pseudomembranous oral candidiasis (8 males, 2 females) received six sessions PDT treatments with methylene blue (450µg/mL) for 2 weeks. Immediately before and after the treatments, C. albicans yeast isolates were recovered to measure the colony-forming units (CFUs ) , and after (15,30,60 days). Patients were assessed for the clinical recovery of oral lesions and improvement of symptoms, and the microbiological evaluation was determined by microbiological collections from the mucosa of the infected area and were seeded and on Sabouraud agar.
Results: this study demonstrates that PDT with MB decreased the CFUs immediately after treatment and decreased the oral lesions and clinical symptoms . There was a relapse at 15,30 and 60 days for clinical and microbiological evaluation.
Conclusions: This clinical study suggests that PDT with MB could reduce the fungal load and improve the clinical symptoms of oral candidiasis in patients undergoing chemotherapy after treatments but still presented observed relapse in clinical and microbiological response after 15,30,60 days
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.