Efficacy of photodynamic therapy in the treatment of Pseudomembranous oral candidiasis


  • husen sliman Damascus University
  • Ammar Mashlah Damascus University
  • Abeer Alkafri Damascus University


Background:   Photodynamic therapy (PDT) using methylene blue (MB) has been shown to be an effective method  for the in vitro and in vivo inactivation of Candida species, however, there  are limited reports of clinical investigations. The aim of this study was to explore the clinical application of  PDT with MB   for the treatment of oral infection caused by C. albicans in patients undergoing chemotherapy.

 Methods: A total of 10 adult patients with pseudomembranous oral candidiasis (8 males, 2 females) received six sessions  PDT treatments with methylene blue (450µg/mL)   for 2 weeks. Immediately before and after the treatments, C. albicans yeast isolates were recovered to measure the colony-forming units   (CFUs  ) , and after (15,30,60 days). Patients were assessed for the clinical recovery of oral lesions and improvement of symptoms, and the microbiological evaluation was determined by microbiological collections from the mucosa of the infected area and were seeded and  on Sabouraud agar.

  Results: this study demonstrates that PDT with MB decreased the CFUs    immediately after treatment and decreased the oral lesions and clinical symptoms . There was  a relapse at   15,30 and 60   days for clinical and microbiological evaluation.

 Conclusions: This clinical study suggests that PDT with MB    could reduce the fungal load   and improve the clinical symptoms of oral candidiasis in patients undergoing chemotherapy after treatments but still presented observed relapse in clinical and microbiological response after 15,30,60  days



How to Cite

سليمان ح, عمار مشلح, عبير الكفري. Efficacy of photodynamic therapy in the treatment of Pseudomembranous oral candidiasis . Tuj-hlth [Internet]. 2022Sep.6 [cited 2024Jun.23];44(4):43-56. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/12635