The Effect of long-term Hydroxychloroquine use on corneal endothelium and thickness


  • Reem Ahmad Tishreen University
  • Yusuf Suleiman Tishreen University
  • Kaser Aldow Tishreen University




To study the relationship between long-term Hydroxychloroquine use and the changes in corneal endothelial cells.


In this  study, 48 eyes of 24 healthy persons  and 48 eyes of rheumatoid patients who used Hydroxychloroquine since a year at least, attending the ophthalmological clinic at Tishreen University Hospital were studied between the years 2021-2022, all participants underwent a complete ophthalmological examination including corneal endothelial cell counts by non contact specular microscopy , where the average of three successive measurements of endothelial cell density (ECD), and hexogram (EX%), coefficient of variation (CV) , central corneal thickness(CCT)were taken.


The values of endothelial cell density (ECD) (P ˂ 0.05) decreased and central corneal thickness (P ˂ 0.05) increased statistically significantly, while the value of the covariance (CV) and hexogram(HEX)  did not have a statistically significant effect    (P> 0.05) from the controls.


Patients using long-term HCQ demonstrated lower ECD and higher CCT than the control group.However, the CV and the HEX values were not significantly different from the controls.


corneal endothelial cells, central corneal thickness, Hydroxychloroquine.



How to Cite

احمد ر, يوسف سليمان, كاسر الدو. The Effect of long-term Hydroxychloroquine use on corneal endothelium and thickness. Tuj-hlth [Internet]. 2022Sep.6 [cited 2024Jun.23];44(4):169-78. Available from: