The Effect of long-term Hydroxychloroquine use on corneal endothelium and thickness

Authors

  • Reem Ahmad Tishreen University
  • Yusuf Suleiman Tishreen University
  • Kaser Aldow Tishreen University

Abstract

 

Objective:

To study the relationship between long-term Hydroxychloroquine use and the changes in corneal endothelial cells.

Methods:

In this  study, 48 eyes of 24 healthy persons  and 48 eyes of rheumatoid patients who used Hydroxychloroquine since a year at least, attending the ophthalmological clinic at Tishreen University Hospital were studied between the years 2021-2022, all participants underwent a complete ophthalmological examination including corneal endothelial cell counts by non contact specular microscopy , where the average of three successive measurements of endothelial cell density (ECD), and hexogram (EX%), coefficient of variation (CV) , central corneal thickness(CCT)were taken.

Results:

The values of endothelial cell density (ECD) (P ˂ 0.05) decreased and central corneal thickness (P ˂ 0.05) increased statistically significantly, while the value of the covariance (CV) and hexogram(HEX)  did not have a statistically significant effect    (P> 0.05) from the controls.

Conclusion:

Patients using long-term HCQ demonstrated lower ECD and higher CCT than the control group.However, the CV and the HEX values were not significantly different from the controls.

Keywords:

corneal endothelial cells, central corneal thickness, Hydroxychloroquine.

Published

2022-09-06

How to Cite

1.
احمد ر, يوسف سليمان, كاسر الدو. The Effect of long-term Hydroxychloroquine use on corneal endothelium and thickness. Tuj-hlth [Internet]. 2022Sep.6 [cited 2024Jun.23];44(4):169-78. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/12658