The Prognostic Value of Pre-treatment Serum Lactate Dehydrogenase Levels in Acute Leukemia

Authors

  • Qamar Sattouf Tishreen University
  • Feras Hussein Tishreen University
  • Muhammad Ayman Awama Tishreen University

Abstract

Objective: Leukemia is a globally increasing disease. Due to the reliance of tumor cells on anaerobic glucose metabolism for energy consumption, serum LDH levels are elevated. This has prompted us to study the prognostic significance of this enzyme to search for a specific, easily analyzable, and cost-effective marker.

Methods: The study included 105 participants: 75 newly diagnosed patients with acute leukemia (40 with acute myeloid leukemia and 35 with acute lymphoblastic leukemia) and 30 healthy individuals. LDH levels were measured using spectrophotometric assay with a Mindray device.

The patient samples were divided into three groups according to serum LDH levels: Group A had LDH levels lower than twice the normal value, Group B had LDH levels between twice and five times the normal value, and Group C had LDH levels greater than five times the normal value.

Results: The Overall survival and Progression-free survival rates were statistically higher in the group with lower LDH levels. There was a significant difference observed among the three patient groups divided according to LDH levels, with overall survival and progression-free survival rates of 93.8% and 68.6%, respectively, in Group A.

Conclusions: Pre-treatment serum LDH levels is an important predictive marker in leukemia patients, with high LDH levels indicating poor prognosis and lower survival rates. LDH can be depended on as a routine, cost-effective, and easily analyzable test.

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Published

2023-09-17

How to Cite

1.
صطوف ق, فراس حسين, محمد أيمن عوامة. The Prognostic Value of Pre-treatment Serum Lactate Dehydrogenase Levels in Acute Leukemia. Tuj-hlth [Internet]. 2023Sep.17 [cited 2024Dec.21];45(4):323-32. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/15522

Issue

Vol. 45 No. 4 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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