Interleukin 8 & C-reactive protein-high sensitive levels as predictive markers to hormo-response in breast cancer subtypes BCSs in Syrian patients

Authors

  • rimal asaad Tishreen University
  • Firas Hussein Tishreen University
  • Zuheir Al-Shehabi Tishreen University
  • Rafea Shaaban Tartous university

Abstract

Breast cancer is a complex disease with different behaviors and responses to hormone therapy resistance. Inflammatory markers like IL-8 and CRP-hs are often elevated in breast cancer patients. This study aimed to characterize breast cancer subtypes and assess IL-8 and CRP-hs levels in patients at Tishreen-University Hospital in Syria from 2020 to 2022.The study included patients who had mastectomy with lymph node dissection, with an average age of 48.04±10.99 years. Results showed that the most common breast cancer subtypes were Luminal A1, TN, and TP. Older patients and those with Luminal B2 subtype had higher IL-8 and CRP-hs levels, but these differences were not statistically significant. There was a significant relationship between breast cancer subtypes and disease stage.In conclusion, most breast cancer patients in this study fell into Luminal A1, TN, and TP subtypes. The higher rate of negative ER-expression in Luminal B2 suggests a greater risk for hormone therapy resistance. Additionally, older patients with Luminal B2 subtype had higher IL-8 and CRP-hs levels. These findings enhance our understanding of breast cancer subtypes, their association with inflammatory markers, and hormone therapy resistance. Further research is needed to validate these results and explore potential therapeutic implications.

Downloads

Published

2023-12-01

How to Cite

1.
asaad rimal, Firas Hussein, Zuheir Al-Shehabi, Rafea Shaaban. Interleukin 8 & C-reactive protein-high sensitive levels as predictive markers to hormo-response in breast cancer subtypes BCSs in Syrian patients. Tuj-hlth [Internet]. 2023Dec.1 [cited 2025Apr.15];45(5):113-24. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/15961

Issue

Vol. 45 No. 5 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.