Study of the effect of plasticizers on the properties of enteric coated diclofenac sodium tablets using Eudragit L

Authors

  • Taimmaa Mansour Tishreen university
  • Tamim Hammad Tishreen University

Abstract

This research aims to study the effect of the type and quantity of plasticizers on the release of diclofenac sodium from its enteric- coated tablets.

Several formulations of enteric coated diclofenac sodium tablets were prepared using Eudragit L as a polymer at a concentration of 2%. The different properties of granules and tablets (before and after coating) were evaluated. The effect of different plasticizers (propylene glycol and Span 80 at concentrations of 15% and 30% by weight of the solid polymer) on the release of diclofenac sodium from enteric-coated tablets was studied. The plasticizers used had no significant effect on the release of diclofenac sodium in 0.1N HCl medium. Whereas the percentage of diclofenac sodium released into the phosphate buffer (pH = 6.8) increases from formulas containing the propylene glycol (PG) plasticizer compared to formulas containing the Span 80 plasticizer. The released percentage of diclofenac sodium also increased by increasing the concentration of PG plasticizer, while the released percentage of diclofenac decreased by increasing the concentration of Span 80 plasticizer.

Downloads

Published

2024-01-31

How to Cite

1.
Mansour T, Tamim Hammad. Study of the effect of plasticizers on the properties of enteric coated diclofenac sodium tablets using Eudragit L. Tuj-hlth [Internet]. 2024Jan.31 [cited 2024Apr.27];45(6):239-55. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/16232

Issue

Vol. 45 No. 6 (2023): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.