Effect of the combination between metformin and lansoprazole on blood glucose levels in diabetic mice
Abstract
Several studies have indicated the ability of gastrin to promote an increase of β cell mass in pancreas, an increase of glucagon-like-peptide-1(GLP-1) secretion and therefore that gastrin may improve glucose tolerance. proton pump inhibitors (PPIs) indirectly elevate serum gastrin levels in animals and humans via a negative feedback effect. Therefore, the aim of the study was to investigate the effect of lansoprazole on blood glucose levels in diabetic mice. Hyperglycemia was induced experimentally in female white albino mice by a single intraperitoneal administration of alloxan monohydrate which dissolved in normal saline. Seven days later, mice with FBG levels ≥150 mg/dL were considered diabetic and used in this study. Mice were allocated to five groups: (normal group), (diabetic group), (DM+lansoprazole group), (DM+metformin group), (DM+Combination group). Fasting blood glucose (FBG) levels and intraperitoneal glucose tolerance test (IPGTT) were determined at the end of the study. LPZ significantly improved glucose metabolism compared with diabetic control group. We found that metformin and lansoprazole were equally effective in reducing FBG levels. Contrary to our expectation, the effects of the combination therapy and metformin mono-therapy on glycemic control were equivalent.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.