Preparation of a gel from rosemary extract and zinc oxide nanoparticles and determination of its antibacterial effectiveness for acne
Abstract
Phytotherapy has been used over the centuries, and interest in it has increased recently. Rosemary extracts contain many active substances of various medical importance, including antibacterial activity. Additionally, zinc oxide nanoparticles have great antibacterial capabilities due to their small size, which can stimulate various mechanisms to eliminate germs. On the other hand, acne affects a large number of teenagers and adults, and both Propionibacterium acnes and Staphylocoocus aureus are among the most common bacterial strains affecting people with acne.
During this study, essential oils were extracted from rosemary leaves and analyzed using GC/MS. It was found that the essential oil of rosemary leaves contains a high content of triterpenoids, monoterpenoids, and phenolic diterpenes, including 32 compounds. Zinc oxide nanoparticles were also prepared chemically and their specifications were verified using a scanning electron microscope to confirm the formation of the nanoparticles. Essential oil and zinc oxide nanoparticles were used to prepare a gel that was uniform, easy to apply, and had a pH suitable for application on the skin. The bacteriological study confirmed the effectiveness of the gel in inhibiting the growth of both P. acnes and S. aureus, as the diameter of the inhibition zone was 17.32±0.92 mm and 23.56±0.67 mm for P. acnes spores and S. aureus spores, respectively. As a result, the prepared gel using the essential oil of rosemary leaves and zinc oxide nanoparticles can be considered an alternative natural formula to combat acne.
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