Comparison of the efficacy of microneedling in the combination with platelet-rich plasma versus microneedling alone in treatment of striae distensae
Abstract
Background: Striae distensae is considered one of the most common popular aesthetic problem especially among younger women. There are many therapeutic options for management, but no consistently effective modality is available yet.
Aim: The purpose of this study was to evaluate the efficacy of combination of microneedling and platelet-rich plasma (PRP) versus microneedling alone in treatment of striae distensae.
Materials and Methods: This was a randomized clinical trial (prospective) conducted for the period one year (2022-2023) in the clinic of dermatology at Tishreen University Hospital in Lattakia. The study included 19 patients with striae distensae who received treatment with microneedling alone and 19 patients who treated with microneedling and platelet-rich plasma(PRP), and final outcome was compared between two methods.
Results: Out of 38 patients, 8 patients (21.1%%) were male and 30 patients (78.9%) were female, with mean age of the patients was 29.34±7.4 years. Striae alba represented the most frequent type of striae (73.7%) and the most affected parts of body were abdomen (31.6%), flank (18.4%) and popliteal fossa (15.8%). There were no significant differences between two groups regarding of demographic and clinical characteristics(p>0.05). Good response occurred in 47.9% of the patients in combination group versus 26.3% in microneedling group, p: 0.03. There was significant difference between two groups regarding of satisfaction, in which 63.2% of the patients in combination group were highly satisfied versus 47.3% in microneedling group, p:0.01. In addition to, there was no association between improvement and the following variables: gender, age, Fitzpatrick skin type, type of striae, and its location (p>0.05).
Conclusion: The current study showed that microneedling with platelet-rich plasma appears to be effective in treating striae distensae.
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