Studying the Effect of Artichoke Bracts and Leaves Extracts on Glucose Tolerance in Experimental Animals
Keywords:
glucose tolerance test, artichoke, bracts, leavesAbstract
Artichoke (Cynara Scolymus) displays many medicinal properties such as antioxidant, anti-inflammatory, hepatoprotective and cholesterol-lowering properties. In addition, it is traditionally used to improve the function of the digestive system.
These numerous effects are attributed to its content of phenolic compounds such as chlorogenic acid derivatives and cynarine. Phenolic compounds are known for their positive effect on sugar metabolism in the body and due to fact that the plant is rich of these compounds, this study aimed to investigate the effect of pretreatment with artichoke leaves and bracts extracts on glucose tolerance in experimental animals. We used previously prepared ethanolic extracts. The extracts were prepared by maceration and they are of known concentrations. Experimental animals were divided into three groups, mice were treated with either leaf extract at a dose of 1g/kg or bracts extract at a dose of 1g/kg or distilled water (normal control group) for seven days and then fasted on the last day for 16 hours before intraperitoneal injection of 10% glucose solution at a dose of 1.5g/kg. Blood glucose levels were measured before glucose injection and after 30, 60 and 120 minutes of glucose loading. The groups treated with artichoke leaf or bracts extract showed similar glucose tolerance to the normal control group and no statistically significant difference was observed in blood glucose levels between the three groups at the four mentioned time points. The reduction in blood glucose levels in leaves extract -treated group was higher compared to the control but without statistical significance difference.
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