Effect of Statins Therapy on Renal Function and CRP Levels in Chronic Kidney Disease Patients
Keywords:
Chronic kidney disease, statin, inflammation, C-reactive protein, eGFRAbstract
Persistent, low-grade inflammation with increased inflammatory markers, like C-reactive protein (CRP), is now considered a hallmark feature of CKD, being involved in the development of cardiovascular and all-cause mortality of these patients. In this study, we aimed to investigate the possible anti-inflammatory effects of statins and their effect on kidney function in predialysis (stage 3-4) and hemodialysis CKD patients.
Seventy-four CKD patients seen at the department of kidney disease and hemodialysis of Tishreen Hospital in Lattakia, were assigned into two groups (a statin group (N=44), and a control group (N=30)). Patients in statin group received either 40 mg of atorvastatin or 10 mg of rosuvastatin daily for 6 months. Serum levels of C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) were measured in both groups at baseline and at the end of the follow period. The levels of lipid profile parameters were also measured.
In statin group, mean serum CRP levels decreased significantly in predialysis (from 5.3±1.9 to 4.7±1.6 mg/l, P <0.001) and in hemodialysis patient (from 5.3±1.6 to 4.6±1.5 mg/l, P<0.001) after 6 months of treatment with statin. In control group, mean CRP values were not significantly changed at the end of 6 months follow up. Statin therapy prevented the regression of eGFR rate with non-significant change after 6 months follow up in both, predialysis and hemodialysis patient CKD, while in control group eGFR declined significantly, from 37.13±15.6 to 30.63±11.4 mL/min/1.73 m2, P=0.046 in predialysed patients and from 6.4±2.6 to 5.2±1.6 mL/min/1.73 m2, P=0.039 in hemodialysis patients, at the end of follow up period. The anti-inflammatory and renoprotective effects were independent of lipid-lowering effect observed with statin therapy. In conclusion, in addition to their beneficial effects on lipid levels, administration of statins could present an anti- inflammatory effect, with a consequential renoprotective effect in CKD patients.
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