الفعالية العلاجية لمركب FLUDARABINE في معالجة مرضى CLL المعندين على المعالجة

Authors

  • سهام سليمان

Abstract

يهدف هذا البحث إلى دراسة فعالية مركب Fludarabine في علاج الابيضاض اللمفاوي المزمن المعند  على العلاجات الأخرى، ودراسة اختلاطات استخدام هذا المركب على المرضى.

أعطيت هذه المعالجة لـ 19 مريضاً شخص لهم CLL، ولم يحققوا أية استجابة على العلاجات الأخرى بجرعة 25 مغ/م2 تسريب وريدي لمدة نصف ساعة يومياً ولمدة 5 أيام يعاد الشوط كل 4 أسابيع (3-6 أشواط). تمت متابعة المرضى سريرياً ومخبرياً كل شهر مرة مع تقييم نقوي كل 3 أشهر.

بنتيجة هذه المعالجة حصل 21% من المرضى على هوادة تامة و 47,36% على هوادة جزئية. استمرت الهوادة التامة 9 أشهر وسطياً ووسطي الحياة 42 شهرا . وكان التثبيط النقوي أهم اختلاطات المعالجة المشاهدة.

The research aims to study the activity of Fludarabine in the treatment of refractory CLL, and its side effects.

Nineteen patients were included in this study, all of whom had been previously treated with another treatment without success. The doses were 25 mg/m2 once daily, 5 days every 4 weeks (3-6 times). Patients were evaluated before treatment, observed during treatment with monthly blood evaluation, three-monthly, bone marrow evaluation, in addition to clinical follow up.

Hematological improvement was observed with complete remission in 4 patients (21%). Partial remission was seen in 9 patients (47.36%) after 6 months of treatment. The CR kept of 9 months. The major complication was bone marrow suppression.

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Published

2019-01-14

How to Cite

1.
سليمان س. الفعالية العلاجية لمركب FLUDARABINE في معالجة مرضى CLL المعندين على المعالجة. Tuj-hlth [Internet]. 2019Jan.14 [cited 2024Nov.24];27(1). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/6318

Issue

Vol. 27 No. 1 (2005): العلوم الصحية

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