دراسة تأثير نوعية الكريمات (ز/م-O/Wأو م/ز- W/O ) على تحرر ديكلوفيناك الصوديوم ( In vitro release system)
Abstract
قورن معدل التحرر (Release Rate ) لمادة ديكلوفيناك الصوديوم باستخدام طريقة الديلزة من خلال استخدام غشاء سيللوزي يحوي المادة الفعالة ضمن وعاء بيشر من الماء المقطر محاط بحمام مائي.
ذلك باستخدام 4 أنماط من الكريمات (A+B م/ز- C+D ز/م ) وهي :
A- أبيض البال + شمع أبيض + بارا فين سائل + ماء + بورات الصوديوم.
B– أبيض البال + فازلين + شمع أبيض + سبان + زيت الفازلين + ماء.
C- حمض الشمع + غول سيتيلي + تري ايتانول أمين + بور أكس + ماء.
D– غول سيتيلي + فازلين أبيض + توين 80 + ماء.
كان تركيز المادة الفعالة (Sodium Diclofenac) 1% في كافة الكريمات المدروسة.
بينت النتائج أن تحرر المادة الفعالة (Sodium Diclofenac) كان أفضل ما يمكن بالعينتينD+C(ز/م) حيث بلغ0.20 mg/ml + 0 .25 mg/ml بعد 80 دقيقة من بداية عملية التحرر (In Vitro), بالمقابل انخفض تركيزها إلى أدنى مستوى في العينتين ِA+B (م/ز) حيث بلغ 0.097 mg/ml و0.104 على الترتيب بعد 80 دقيقة من بداية عملية التحرر (In Vitro),
The release rate of sodium diclofenac has been studied in vitro dialysis system. The substance was suspended in cellulosic bag, intoshaked & thermostatic water. 4 types of creams (A+B: W/O & C+D: O/W) were compared. The composition of different creams were:
- Sperma cite + White wax + Liquid Paraffin + Water + Borax,
- Sperma cite + White wax + Liquid Paraffin + Water + Span,
- Stearic Acid + Cetyl alcohol + Triethanolamin + Water + Borax, and
- Cetyl alcohol + White vaselin + Water + Twwen 80.
The drug concentration is 1% in all treatments.
The release rates of the drug was higher in the case of O/W cream type.
These release rates of the drug were: 0.104, 0.097, 0.25, 0.20 mg/ml/80 min, for the treatments A,B,C & D successively.
Drug releasing was higher in treatment C, O/W type, (0.25mg/ml/80 min), whereas this releasing was lower in the treatment B, W/O type,(0.097 mg/ml/ 80 min).
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