العلاقة بين نسبة الكريات الحمر الشائكة ودرجة قصور الكبد المزمن

Authors

  • حسان زيزفون
  • رياض جالق
  • عصام ديب

Abstract

شملت الدراسة 48 مريضاً مصاباً بداء كبدي مزمن و/أو تشمع, راجعوا مشفى الأسد الجامعي قسم الأمراض الباطنة خلال العام 2003. تم تصنيف المرضى وفق نظام تشيلد - بوف المعدل إلى ثلاث مجموعات. شكل مرضى Child's A المجموعة الأولى حيث بلغ عددهم 8 ونسبتهم 16.6% وبلغ متوسط نسبة الكريات الشائكة عندهم 1.875 ± 0.413%. وشكل مرضى Child's B المجموعة الثانية وبلغ عدهم 18 مريضاً 37.5% وبلغ متوسط نسبة الكريات الشائكة لديهم 3.844 ± 0.095% بينما شكل مرضى Child's C المجموعة الثالثة وبلغ عددهم 22 مريضاً 45.8% ومتوسط نسبة الكريات الشائكة 7.2 ± 0.555%.

لقد ظهر وجود فروق جوهرية كبيرة جداً بين نسبة الكريات الشائكة في المجموعات الثلاث
(F = 0.05 و0.01)، كما لوحظ وجود فوارق جوهرية بين متوسطات نسب الكريات الشائكة (P = 0.01 وP = 0.001) مما يثبت أن الكريات الشائكة ترتفع في الدم المحيطي لدى مرضى الداء الكبدي المزمن و/أو التشمع مع تقدم درجة القصور الكبدي وبالتالي يمكن أن يعتبر علامة تشير لسوء الإنذار. لقد كانت النسبة لدى مرضى التشمع الكحولي ذوي التصنيف Child's C 7.91 ± 0.183% أعلى منها لدى مرضى Child's C العائد للتشمع النخري6.82 ± 0.149% ومرضى Child's C العائد لتشمع خفي المنشأ 6.36 ± 0.094% (الفارق جوهري عند P = 0.01 و0.001) مما يعني أن الكريات الشائكة تكون أكثر ارتفاعاً عند مرضى الداء الكبدي الكحولي مقارنة بأسباب التشمع الأخرى.

The study included 48 patients with chronic liver disease with/or cirrhosis visited or admitted to Al-Assad university hospital - department of internal medicine during 2003. According to the modified child - pugh system, patients were classified into 3 groups. First group was child's A patients, they were 8 patients (16.6%) with annithamic mean of acanthocytic ratio (1.875 ± 0.413%). Child's B patients were the second group, they were 18 patients (37.5%) and annithamic mean of acanthocytic ratio was (3.844 ± 0.095%). The last 22 patients with child's C were the third group (45.8%) with annithamic mean (7.2 ± 0.555%) for acanthocytes. There were significant differences among the groups. (F = 0.05 & 0.01) and between the annithamic means for acanthocytic ratio (P = 0.01 & 0.001). these findings mean that acanthocytes increase in peripheral blood of patients with chronic liver disease with/or cirrhosis with the progress of hepatic failure and may considered as a sign of bad prognosis. The ratio of acanthocytes in child's C patients with alcoholic liver cirrhosis (7.91 ± 0.183%) was greater than child's C  patients with post-necrotic cirrhosis (6.82 ± 0.149%) and child's C  patients with cryptogenic cirrhosis (6.36 ± 0.094%) and the difference was significant
(P = 0.01 & P = 0.001).

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Published

2019-02-19

How to Cite

1.
زيزفون ح, جالق ر, ديب ع. العلاقة بين نسبة الكريات الحمر الشائكة ودرجة قصور الكبد المزمن. Tuj-hlth [Internet]. 2019Feb.19 [cited 2024Apr.28];26(2). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/8159

Issue

Vol. 26 No. 2 (2004): العلوم الصحية

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