Effectiveness of Localized Injection of Botulinum Toxin versus Localized Injection of Steroids (Triamcinolone) in the Treatment of Keloids

Authors

  • Abdelhaleem Roumieh
  • Amani Mayhoub

Abstract

Objective: Keloid pose aesthetic and functional problems, in addition to being associated with disturbing clinical symptoms such as itching and pain, and current methods of treatment are limited in effectiveness. Clinical studies indicate that botulinum toxin (BTA) may prevent the formation of keloid and treat it, so the aim of this research was to compare the effectiveness of topical injection of botulinum toxin versus topical steroid injection in the treatment of keloid.

Methods: The research sample included 23 patients from the dermatology clinic at Tishreen University Hospital in Lattakia between 2019 and 2020, with keloids. The number of keloids registered with the studied sample was 30 distributed to two groups: Group A receiving IL steroid repeated every 4 weeks for six sessions, Group B IL BTA 5 IU /cm3 repeated every 8 weeks for three sessions. Objective parameters (hardness, elevation, pigmentation and vasscularity), subjective complaints (itching, pain, and tenderness), patient satisfaction, and side effects were evaluated.

Results: There was a 58.4% decrease in the Vancouver scale for group A, and 65.8% for group B, without a statistical difference between the two groups (P <0.05). A noticeable decrease in tenderness 85.9% in treatment group A and 82.7% in treatment group B. A significant decrease in elevation in A 79.4% while B had a slight decrease of 27%. For vascularity we observed a slight decrease in treatment group A of 17.7% without statistical significance, whereas in treatment group B there was a decrease of 58%. The itching improvement in treatment group B was shown to be greater with statistically significant differences (P<0.05). Skin atrophy and telangiectasia were evident in 11 patients of group A.

Conclusions: This study showed the efficacy and safety of topical toxin injection in treating keloid by improving objective and subjective criteria when compared to topical injection of corticosteroids. With fewer side effects reported for botulinum toxin.

 

Downloads

Published

2020-08-01

How to Cite

1.
رومية عا, ميهوب أ. Effectiveness of Localized Injection of Botulinum Toxin versus Localized Injection of Steroids (Triamcinolone) in the Treatment of Keloids. Tuj-hlth [Internet]. 2020Aug.1 [cited 2024Dec.26];42(3). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/9771

Issue

Vol. 42 No. 3 (2020): Tishreen University Journal for Research and Scientific Studies - Medical Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)