Preparation and in-vitro Evaluation of Zolmitriptan Nasal SemiSolid Formulations

Authors

  • Mohammad Othman Tishreen Journal
  • Haya Barakat

Abstract

This study aims to prepare SemiSolid nasal Formulations, of Zolmitriptan "anti-migraine" to investigate their physiochemical properties and in-vitro release studies, in order to improve their Pharmacokinetics and therapeutic properties, this study has started by using a pure Zolmitriptan Ultraviolet absorption (UV Spectrophotometery), Fourier Transformation Infra Red (FTIR), Differential Scanning Calorimetry (DSC), and X-Ray Diffraction (XRD) of the drug and the excipients looking for possible interactions between them. Zolmitriptan gels, creams (Emulgel), and ointments were prepared. The experiments showed that the formulation of Zolmitriptan gels based on carbopol 940 were the best among the formulas, in terms of rapid in-vitro releases of the drug, by using an (Enhancer cell).

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Published

2020-10-01

How to Cite

1.
عثمان م, بركات ه. Preparation and in-vitro Evaluation of Zolmitriptan Nasal SemiSolid Formulations. Tuj-hlth [Internet]. 2020Oct.1 [cited 2024May5];42(4). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/9865

Issue

Vol. 42 No. 4 (2020): Tishreen University Journal for Research and Scientific Studies - Medical Sciences Series

Section

Articles

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