Effect of Coastal Climate on Chemical Stability of Commercial Ranitidine Tablets by using Derivative Spectrophotometry (DS)

Authors

  • Hala Barakat Tishreen Journal
  • Mohammad Haroun
  • Yasmin Jarjour

Abstract

The stability of commercial Rantidine tablets (150 mg) from four local companies and one foreign company was studied. Tablets were exposed to three different conditions of temperature and humidity for six months, and storage on shelf for 12 months.

Derivative Spectrophotometry (DS) was used for determination the ranitidine in its tablets. The weight difference method was used to investigate tablets moisture absorption.

The results showed change in the color and smell of the tablets by storing in the accelerated conditions, decrease in the content of Rantidine tablets (less than 90%) for all companies, while the C company remained within the specified range. By storing on the shelf the content remained within the range specified, despite the percent degradation ranged between 15-20%.

Degradation of Ranitidine increased with temperature and humidity increasing, but the effect of moisture on stability was greater than the effect of temperature. Tablets of all companies, including foreign one, showed an increase in weight because of moisture absorption, which increased with humidity increasing at a constant temperature. This study also showed C company as the best local company in terms of its resistance to degradation and moisture absorption, unlike Company B, which showed rapid and significant degradation compared with other companies.

Downloads

Published

2020-10-01

How to Cite

1.
بركات ه, هارون م, جرجور ي. Effect of Coastal Climate on Chemical Stability of Commercial Ranitidine Tablets by using Derivative Spectrophotometry (DS). Tuj-hlth [Internet]. 2020Oct.1 [cited 2024Nov.24];42(4). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/9879

Issue

Vol. 42 No. 4 (2020): Tishreen University Journal for Research and Scientific Studies - Medical Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)

1 2 > >>