Latakia University Journal -Medical Sciences Series

Orthopaedic Implants Failure At Environment Of Infection

Ahmad Jouny — Sun, 16 Feb 2025 00:00:00 +0000

This study included (93) cases of Orthopaedic implant failure: (65) ORIF and (28) prostheses at environment of infection.

Infection created suitable conditions for the failure of the orthopedic implant through different mechanisms, the most important of which is bone resorption around the implant. Several factors contributed to the high rate of failure in conditions of infection related to the type of implant, its efficiency, the condition of the bone in which it was implanted, some incorrect surgical techniques, and the level of health awareness of the patient.

The study showed the existence of a negative two-way reciprocal relationship between the failure of the orthopedic implant and the development of infection around it.

The orthopedic implant that failed was removed in most cases, and in some special cases where keeping the implant was an urgent requirement, the implant was kept (14) cases with all the usual measures taken to treat infection. These cases were of mild degrees that were detected early in conditions of low-effective infection and a good immune status of the patient.

Assessment Of Dental Caries And Oral Health Care In Children And The Impact Of School On Them (Cross-sectional study)

فائق بدر — Sun, 16 Feb 2025 00:00:00 +0000

Introduction: Dental caries remains the most prevalent disease among humans and is particularly common in children aged 5 to 17 years, according to World Health Organization statistics from 2022. Schools and communities play a significant role in public and dental health by reducing the spread of diseases through awareness and timely management.

Objective of the Study: To assess the impact of schools (public and private) on the prevalence of dental caries and caries risk assessment, frequency of tooth brushing, and number of dental visits.

Materials and Methods: This cross-sectional study included 370 children from public and private schools in the city of Latakia, aged between 6 and 10 years.

Their teeth were examined to evaluate the prevalence of caries and caries risk assessment using the DMFT/dmft index. Additionally, a questionnaire was used to assess oral healthcare practices.

Results: There were no statistically significant differences in the prevalence of dental caries, caries risk assessment, frequency of tooth brushing, or number of visits to the dentist between public and private schools.

Conclusion: The current study found that whether a child attends a private or public school does not affect the prevalence of dental caries, caries risk assessment, oral health care practices.

Chronic large pericardial effusion due to a metal wire migrated from inferior vena cava filter diagnosed accidentally during surgery- a case report

mudar abdullatif — Sun, 16 Feb 2025 00:00:00 +0000

Background: In this case, we present a chronic complication that should be kept in mind when examining any patient with inferior vena cava filter. One of its most important complications is the migration of a segment of it.

Case Summary: We present here a case of a metal wire migrating from the inferior vena cava filter that led to a large chronic pericardial effusion in an obese patient, and because of the failure of the pericardiocentesis attempt, it was decided to perform a pericardial window. Fortunately for the patient, the diagnosis was made during surgery and the metal wire was extracted.

Discussion: What distinguishes this case is the chronic course For the case, unlike the cases documented before us with an acute course, and because the complaint is chronic, we did not think of the potential traumatic damage of the inferior vena cava filter.

Studying the Effect of Artichoke Bracts and Leaves Extracts on Glucose Tolerance in Experimental Animals

noma hasan — Sun, 16 Feb 2025 00:00:00 +0000

Artichoke (Cynara Scolymus) displays many medicinal properties such as antioxidant, anti-inflammatory, hepatoprotective and cholesterol-lowering properties. In addition, it is traditionally used to improve the function of the digestive system.

These numerous effects are attributed to its content of phenolic compounds such as chlorogenic acid derivatives and cynarine. Phenolic compounds are known for their positive effect on sugar metabolism in the body and due to fact that the plant is rich of these compounds, this study aimed to investigate the effect of pretreatment with artichoke leaves and bracts extracts on glucose tolerance in experimental animals. We used previously prepared ethanolic extracts. The extracts were prepared by maceration and they are of known concentrations. Experimental animals were divided into three groups, mice were treated with either leaf extract at a dose of 1g/kg or bracts extract at a dose of 1g/kg or distilled water (normal control group) for seven days and then fasted on the last day for 16 hours before intraperitoneal injection of 10% glucose solution at a dose of 1.5g/kg. Blood glucose levels were measured before glucose injection and after 30, 60 and 120 minutes of glucose loading. The groups treated with artichoke leaf or bracts extract showed similar glucose tolerance to the normal control group and no statistically significant difference was observed in blood glucose levels between the three groups at the four mentioned time points. The reduction in blood glucose levels in leaves extract -treated group was higher compared to the control but without statistical significance difference.

Effect of Statins Therapy on Renal Function and CRP Levels in Chronic Kidney Disease Patients

afraa zrieki — Sun, 16 Feb 2025 00:00:00 +0000

Persistent, low-grade inflammation with increased inflammatory markers, like C-reactive protein (CRP), is now considered a hallmark feature of CKD, being involved in the development of cardiovascular and all-cause mortality of these patients. In this study, we aimed to investigate the possible anti-inflammatory effects of statins and their effect on kidney function in predialysis (stage 3-4) and hemodialysis CKD patients.

Seventy-four CKD patients seen at the department of kidney disease and hemodialysis of Tishreen Hospital in Lattakia, were assigned into two groups (a statin group (N=44), and a control group (N=30)). Patients in statin group received either 40 mg of atorvastatin or 10 mg of rosuvastatin daily for 6 months. Serum levels of C-reactive protein (CRP) and estimated glomerular filtration rate (eGFR) were measured in both groups at baseline and at the end of the follow period. The levels of lipid profile parameters were also measured.

In statin group, mean serum CRP levels decreased significantly in predialysis (from 5.3±1.9 to 4.7±1.6 mg/l, P <0.001) and in hemodialysis patient (from 5.3±1.6 to 4.6±1.5 mg/l, P<0.001) after 6 months of treatment with statin. In control group, mean CRP values were not significantly changed at the end of 6 months follow up. Statin therapy prevented the regression of eGFR rate with non-significant change after 6 months follow up in both, predialysis and hemodialysis patient CKD, while in control group eGFR declined significantly, from 37.13±15.6 to 30.63±11.4 mL/min/1.73 m², P=0.046 in predialysed patients and from 6.4±2.6 to 5.2±1.6 mL/min/1.73 m², P=0.039 in hemodialysis patients, at the end of follow up period. The anti-inflammatory and renoprotective effects were independent of lipid-lowering effect observed with statin therapy. In conclusion, in addition to their beneficial effects on lipid levels, administration of statins could present an anti- inflammatory effect, with a consequential renoprotective effect in CKD patients.

The effect of high-intensity interval training (HIIT) on the weight, mass index, and percentage of fat in the human body

majd issa — Sun, 16 Feb 2025 00:00:00 +0000

The research aimed to identify the effect of high-intensity interval training (HIIT) on the weight, mass index, and percentage of fat in the human body. The research sample was selected from first-year male students of the Faculty of Physical Education - Tishreen University, aged 19 years, and their number was 30 students. The researcher used the experimental method. In the one-group method, pre- and post-test, the body weight, mass index, and fat percentage of the sample members were taken. Then the training program was applied over a period of 12 weeks. The program was divided into 4 stages, each stage lasting 3 weeks. After completing the training program, the change in each of the following was measured. Body weight, mass index, and fat percentage for sample members.

The data were analyzed using statistical methods (arithmetic mean, standard deviation, and t-test).

The results of the study concluded:

- There is a positive effect of high-intensity interval training on reducing body weight

- There is a positive effect of high-intensity interval training on reducing body mass index

- There is a positive effect of high-intensity interval training on reducing the percentage of body fat.

The Relationship Between Mental Imagery and Learning Basic Volleyball Skills for Beginners

Yamen Chhiede — Sun, 16 Feb 2025 00:00:00 +0000

This study aimed to explore the relationship between the level of mental imagery and the learning of basic volleyball skills among beginner students in the College of Physical Education. To achieve this, a descriptive approach was utilized with a sample of 50 male freshmen who had not regularly practiced volleyball or any other sport. The level of mental imagery was assessed using a standardized questionnaire, while skill performance was evaluated by five specialized judges using a carefully designed evaluation form. The results revealed a positive correlation between the level of mental imagery and the learning of basic volleyball skills. Additionally, it was found that the group with a high degree of mental imagery demonstrated better learning outcomes in basic volleyball skills compared to the group with lower levels. These findings suggest that students with higher levels of mental imagery were more capable of learning and performing volleyball skills effectively than those with lower levels of mental imagery.

Statistical Clinical Study on the Importance of Porcelain-Fused-to-Metal Restorations

أنور كلّو — Sun, 16 Feb 2025 00:00:00 +0000

This clinical study aimed to evaluate the effectiveness of porcelain-fused-to-metal crowns and bridges in achieving functional, aesthetic, and anatomical aspects. The study included 60 clinical cases that were monitored regularly over a period of three years. The sample comprised 38 female patients (63.33%) and 22 male patients (36.66%), with cases distributed by age into 39 cases for individuals under the age of 40 (65%) and 21 cases for those over 40 (35%). The cases included 24 single crowns (40%) and 36 bridges (60%).

Three types of metals were used in the fabrication of these restorations: nickel-chromium in 52 cases (86.66%), palladium-gold in 3 cases (5%), and palladium-silver in 5 cases (8.33%). The success criteria included achieving aesthetic appearance, stability, and functional capability of the restorations. During the follow-up period, the results showed that all cases were stable and successful without any significant functional or aesthetic failures, except for one case (1.66%) that required repair due to porcelain fracture caused by night grinding, which was successfully corrected.

The study concluded that porcelain-fused-to-metal crowns and bridges provide a safe and effective option for dental restorations, combining the durability derived from metal reinforcement with the beauty offered by porcelain. The results emphasize the necessity of selecting appropriate metals and ensuring precision in all manufacturing stages to achieve the best outcomes and reduce failures. The study recommends further research on the factors influencing the long-term performance of these restorations, focusing on improving materials and bonding techniques.

A New Approach to Managing Ciliary Body and Choroidal Detachment After Trabeculectomy Surgery

Seyed Mostafa Barsi, Mahmoud Rajab, Afraa Salman — Sun, 16 Feb 2025 00:00:00 +0000

Choroidal detachment (CD) is defined as the abnormal presence of fluid or blood in the space above the choroidal detachment, which is the area between the ciliary body and the sclera, and it has two forms: serous and hemorrhagic. Serous choroidal detachment is one of the recurrent complications of glaucoma surgery. The causes of choroidal detachment, especially in the context of glaucoma surgery, involve various factors, including the disruption of the normal fluid dynamics within the eye, as well as surgical factors; traumatic surgical maneuvers inside the eye and the use of anti-scarring agents during glaucoma surgery can be responsible.

We utilized a specific type of glaucoma surgery (inverted pericardial graft in minimally invasive glaucoma surgery). This study was conducted at the Eye Department of Tishreen University Hospital in Lattakia during 2022, and the sample included 10 patients aged between 20 and 78 years. The standard surgical procedure was performed with a male-to-female ratio of 50/50. The mean intraocular pressure in the sample before surgery was 32.05 mmHg, and we reduced the intraocular pressure to a mean of 18 ± 2 mmHg preoperatively using diuretics. The following factors were evaluated: intraocular pressure after surgery (with a mean of seven readings using the Goldman applanation tonometer recorded for 7 consecutive days after the sclerostomy was cut). We used B-scan ultrasound and clinical diagnosis to detect choroidal detachment.

Among the ten patients, we identified 4 patients (40%) who suffered from choroidal detachment. The average time between sclerostomy and choroidal detachment was 2 ± 1 days. The intraocular pressure at the time of choroidal detachment was significantly low. Patients with choroidal detachment were treated with serum (saline and mixed solution). Steroids were administered from the first day, and post-surgery all patients received subconjunctival injections of gentamicin and dexamethasone immediately. All patients showed improvement within 7 days.

Sodium plays an important role in the production of aqueous humor, as it stimulates the ciliary body through its secretion of aqueous humor, which is initially suppressed by anti-glaucoma medications before surgery. Additionally, glucose plays a supportive role in rejuvenating the ciliary body as it serves as a vital fuel for it.

In conclusion, serum helps in the treatment of choroidal detachment, reduces the required treatment duration, and, in addition, can aid in better recovery. We suggest conducting future studies on the administration of mixed serum during surgery and its immediate effects in preventing choroidal detachment following sclerostomy.

Clinical Leadership Practice in the Clinical Environment Among Heads of Nursing Divisions

Atef Belal — Sun, 16 Feb 2025 00:00:00 +0000

Chief Nursing Officers play an important role in providing ongoing clinical leadership and accountability for quality care and quality improvement efforts. Therefore, this leadership is critical to achieving high-quality nursing outcomes, and therefore enhancing clinical leadership among front-line nurses is critical due to its potential impact on patient outcomes and experiences, team performance outcomes, nurse job satisfaction and retention, and the quality and effectiveness of nursing care. Therefore, the aim of this research was to evaluate the level of clinical leadership practices in the clinical environment among heads of nursing divisions. This research was conducted at Tishreen University Hospital and the National Hospital in the city of Lattakia on a sample of 40 nursing department heads. The results of the research showed that the level of clinical leadership practices of the nursing department heads was high. It also showed that all aspects of clinical leadership were at a high level, except for the axis of establishing a shared vision, which came at middle level. Therefore, the research recommends conducting training programs for heads of nursing divisions in order to improve their clinical leadership practices with regard to establishing a common vision among the work team, and conducting further studies and research on clinical leadership on larger samples.

Evaluation of Enhancements in Trabeculectomy Technique Using a Self-Regulating Valve for Glaucoma Treatment

Sayed Mustafa Barsi, Mahmoud Ahmed Ragab, Afra Salman — Sun, 16 Feb 2025 00:00:00 +0000

This study aimed to evaluate an innovative trabeculectomy technique that utilizes an inverted scleral flap functioning as a self-regulating valve for the treatment of glaucoma. The study included 50 patients (40% male, 60% female) with a mean age of 62.7 years. This technique was developed to overcome the challenges associated with traditional trabeculectomy, such as scar formation, canal blockage, and infections, which lead to failure rates of 5-10% within the first year. The innovative valve operates as a one-way mechanism, allowing aqueous humor outflow when intraocular pressure (IOP) is elevated and automatically closing under low IOP, thereby reducing the risks of hypotony and infection.

Preoperative evaluations included measuring visual acuity, assessing the anterior chamber using the Shaffer and Van Herick classifications, and conducting a fundus examination. Postoperative results demonstrated statistically significant improvements in the visual field (notable enhancement in Mean Deviation [MD] and Pattern Standard Deviation [PSD], p<0.05), as well as a reduction in the need for medications from an average of three drops before surgery to one drop after surgery.

The results indicate that the use of the self-regulating valve represents a significant advancement in glaucoma surgery, demonstrating effectiveness in reducing intraocular pressure while minimizing common complications. However, further studies with larger sample sizes and longer follow-up durations are necessary to determine the long-term benefits and the impact of this technique on patients' quality of life.

Evaluating the Efficiency of Using the Alar Flap in Primary Repair of Complete Unilateral Cleft Lip

Hala Ashkar, Hikmat Yaqoub — Sun, 16 Feb 2025 00:00:00 +0000

Objective of the Study:

The study aims to provide an initial evaluation of the effectiveness of the nasal wing flap technique in the primary repair of unilateral complete cleft lip.

Materials and Methods:

The study included 10 patients (5 males and 5 females) aged between 3 to 6 months, who had not undergone any prior surgical intervention on the lip. The study aimed to assess lip and nasal symmetry 15 days and 6 months postoperatively. This small sample size was selected to conduct an exploratory study focusing on the clinical feasibility of the technique before conducting larger studies. Clinical monitoring involved taking frontal photographs of the patients to evaluate lip and nasal symmetry at 15 days and 6 months after the surgery.

Results:
The results showed an improvement in the height of the cutaneous lip 15 days after surgery, with the mean value of the difference in cutaneous lip height between the cleft and non-cleft sides being 15.10. This improvement persisted at 6 months postoperatively, with no statistically significant difference in the cutaneous lip height difference between 15 days and 6 months post-surgery (p-value > 0.05). The results also demonstrated vertical symmetry of the nasal wings 15 days after surgery, which was maintained at 6 months postoperatively.

Conclusion:
This preliminary study suggests that the nasal wing flap technique may be promising but requires further evaluation in future studies with larger sample sizes and longer follow-up periods.

Study of Serum C - Reactive Protein / Albumin Ratio and its Relationship with Activity and Treatment of Rheumatoid Arthritis

هيا جوني — Sun, 16 Feb 2025 00:00:00 +0000

Background: Rheumatoid arthritis is a chronic systemic disease that primary target the synovium leading to synovial inflammation and proliferation loss of articular cartilage and erosion of juxta articular bone.

Acute phase reactants increase in rheumatoid arthritis and albumin levels decrease. due to proinflammatory cytokines effects.

It is important to find a noval and easier.predictive marker to evaluate the severity of rheumatoid arthritis so we study the correlation between car and das28esr.

The main objective: To study the relationship between CAR and disease activity of rheumatoid arthritis by using DAS28ESR.

Secondary objectives: the study of the realationship between CAR and the treatment of Rheumatoid Arthritis. 1.

Find Cut off values for CAR by dividing RA patients into two groups Early and Eastablished RA and dividing each group of them into another two groups by using DAS28ESR.

Methods: This was a cross sectional study.involved 60 patients with proven diagnosis of rheumatoid arthritis admitted at the department of rheumatology Tishreen University Hospital Lattakia during 2023- 2024

We study the relationship between c reactive protein and albumin using das28 esr the patients were classified in two groups according to the duration of disease.early and established to study the value of cut of for car

Results and discussion: the current study of 60 patients with rheumatoid arthritis showed that the proportion of females with rheumatoid arthritis was higher than men with rheumatoid arthritis 2.8:1, 73.3% female.

And showed strong significant relationship between car and das28esr and esr and strong negative relationship between.das28esr and albumin levels

No relationship between car and the medication used to treat rheumatoid arthritis and between car and rheumatoid factor.

Evaluation of the Effectiveness of the "Modified Frenectomy Technique with Papilla preservation flap" in Upper Lip Frenectomy Accompanied by Diastema Between central Incisors

Wadie Sayegh, Ali Khaleel, Tohama Youssef, Tohama Youssef — Sun, 16 Feb 2025 00:00:00 +0000

Introduction: Cosmetic concerns among patients have led to an increased interest in seeking dental treatment in order to achieve an ideal smile. Diastema between central incisors is a common cosmetic problem that affects the functional aesthetics of teeth.

Aim: looking for new technique for upper lip frenectomy for patients who suffer of diastema between upper central incisors and avoiding negative effects of the traditional technique.

Material & Methods: 10 patients were treated by modified frenectomy and papilla preservation flap. Scar formation was observed after 3 months and pain was observed in the first week after surgery.

Results: modified frenectomy and papilla preservation flap technique helped by avoided scar formation in region of between central incisor papilla in 9 patients of 10.

Patients didn’t suffer from severe pain and its rate was 1.5 for the first day, 4.5 for third day and 0.7 for seventh day.

Conclusion: modified frenectomy and papilla preservation flap technique is a good substitute for conventional technique and easy for work in cases of frenectomy with diastema between central incisors.

In Vitro Evaluation of Shear Bond Strength with OrthGuide Computer-Aided Indirect Bonding Variables: Tray Design Versions and Composite Texture

Hasan Aldaher, shadi Moawad — Sun, 16 Feb 2025 00:00:00 +0000

Objective: This laboratory study aims to conduct a comparison between two indirect adhesive methods that share modern computer-assisted design and manufacturing with regard to measuring the ability of orthodontic brackets to resist shear forces applied to them during the treatment period , in addition to investigating the existence of a correlation between the quality of the adhesive used and its ability to reach the top resistant to the aforementioned forces.

Materials and Methods: The research sample consisted of 60 newly extracted upper premolars that were distributed into 4 groups according to the method of designing the orthodontic bracket molds and the type of adhesive material used in them. American mini master 0.022 MBT brackets were affixed to all of them using 3D printed resin holders and trays of Thermally plasticized polyvinyl siloxane, using two types of light curing composites and dual curing ones. Then, the resistance of these adhesive brackets to shear forces was tested through a set of appropriate laboratory tests.

Results: The results of this study showed that the greatest value of resistance to shear bond strength was in the group of brackets affixed via 3D printed resin holders and light cured composite, while there were no significant differences between the rest of the groups.

Conclusions: Bonding metal orthodontic brackets using 3D-printed holders produced sufficient bond strengths to meet clinical needs. Also, brackets bonded to thermoplastic trays did not show adequate strength when it tested, even with the use of two types of adhesive materials in the study.

Changes in Blood Glucose and Electrolytes (Na-K-CL) During Transurethral Resection of the Prostate Using Dextrose 5% Solution as Irrigation Fluid

merna suliman — Sun, 16 Feb 2025 00:00:00 +0000

Background: As it has been shown in many studies, the rareness of changes in sreum glucose and electrolytes by using dextrose 5% solution during TURP leads to considering it as a good option for using due to its effectiveness, low pric, and lack of significant effects causes by other solutions. Thus we can adopt it as basic solution during TURP.

Objectives: the main objective: Studying the level of serum glucose and electrolytes and its effect on TURP.

Evaluation of the chemical Analysis results before and after surgery.

Secondary objective: Studying the correlation of patient's clinical condition with the results of chemical analysis

Materials and methods: Statistical Study ( cross-sectional) The research sample included 100 patients with benign prostatic hyperplasia who attended the Urological Surgery Clinic at Tishreen University Hospital in Lattakia during the period between 2023-2024 and met the inclusion criterions in the research.The diagnosis of BPH was made clinically .Serum glucose was measured in the central laboratory at Tishreen University Hospital using a semi – automatic HUMAN device, using the colorimetric test method and electrolytes was measured using Urit 910 plus device

Results: Patients' ages ranged from 49 to 82 years, with a mean of 63.93±7.2 years. The mean volume of the prostate before surgery was 56.27±4.9 gram, the mean number of irrigation units used was 14.74±3.2 liter, the mean duration of surgery was 58.80±7.9 minute. The mean level of glucose before surgery was 103.34±24.56 mg/dL. One hour after the end of surgery, it increased and reached 120.45±40.4 mg/dL, and after two hours it decreased again and reached 104.21±30.8 mg/dL with p-value=0.0001 The mean level of sodium before surgery was 139.22±3.5 mmol/L. One hour after the end of surgery it decreased and reached 137.94±3.9 mmol/L, after two hours it returned to the rise and the mean was 138.65±3.6 mmol/L with p-value = 0.01. The mean level of potassium before surgery was 4.12±0.3 mmol/L. One hour after the end of surgery, it increased slightly and reached 4.23±0.4 mmol/L, and after two hours it decreased slightly and reached 4.16±0.3 mmol/L, with p-value=0.03. The mean chloride level before surgery was 100.51±2.18 mmol/L. One hour after the end of surgery, it increased slightly and reached 102.00±2.19 mmol/L, and after two hours it decreased slightly and reached 101.18±2.0 mmol/L, with p-value=0.04. None of our patients had TUR Syndrome.

The mean values of glucose were high in the presence of diabetes and high blood pressure, with statistically significant differences at each follow-up time point with p-value<0.05. The mean values of sodium were low in the presence of diabetes with statistically significant differences at each follow-up time point with p-value<0.05 The mean values of potassium were high in the presence of diabetes and hyperlipidemia, with statistically significant differences at each follow-up time point with p-value<0.05. The mean values of chloride were high in the presence of diabetes, pulmonary disease, as well as the presence of hyperlipidemia, with statistically significant differences at each follow-up time point with a p-value < 0.05

Conclusion: We propose the use of 5% dextrose solution as an irrigation fluid during surgery. We recommend controlling glucose concentration before surgery, especially in diabetic patients

Study of the Relationship between Iron Deficiency Anemia and Recurrent Aphthous Stomatitis

Bashar Ghareer, Ammar Amon — Sun, 16 Feb 2025 00:00:00 +0000

Objective: This study aims to investigate the relationship between iron deficiency anemia and recurrent aphthous stomatitis by evaluating blood hemoglobin levels, mean corpuscular volume, and ferritin levels in patients with recurrent aphthous stomatitis.

Materials and Methods: Blood tests were conducted on thirty patients with recurrent aphthous stomatitis between December 2021 and December 2023, representing the study group. Thirty age and gender-matched individuals were selected as the control group. Hemoglobin levels, mean corpuscular volume, and ferritin concentration in the blood were compared between the two groups.

Results: The sample included 60 patients ranging in age from 16 to 37 years, with a mean age of 26.74 years. The average hemoglobin concentration in the blood within the study group was 10.78 g/dL, while it was 12.45 g/dL in the control group. The mean corpuscular volume within the study group was 82.07, while it was 87.06 in the control group. The average ferritin concentration within the study group was 82.07, while it was 87.06 in the control group. Blood hemoglobin levels, mean corpuscular volume, and ferritin concentration were statistically higher in the control group compared to the study group.

Evaluation of the Short-Term Functional Outcomes of Total Hip Arthroplasty with Hip Osteoarthritis

حيدر حيدر — Sun, 16 Feb 2025 00:00:00 +0000

The importance and justification of the research:

Prevalence of hip osteoarthritis in people over 40 years old. Functional disorders caused by hip osteoarthritis, which may lead to permanent partial disability in some cases. The great development that has occurred in surgical techniques and artificial materials which contributed to improving the results of total hip arthroplasty.

The Aim:

The aim of this study is to improve functional outcomes in patients with hip osteoarthritis who underwent total hip arthroplasty (THA), and to evaluate the clinical and radiological outcomes. Also to reduce the complications, and to correlate the results with the type of surgical approach.

Patients and methods:

Between 2018 and 2021, An analytical comparative study (retrospective), was done on 57 patients with hip osteoarthritis who underwent total hip arthroplasty was evaluated for functional results. We compare these results using many variables: age, sex, type of artificial joint, body mass index (BMI), and functional state of the patient and hip before and after surgery using WOMAC index (Western Onterio and McMaster Universities Osteoarthritis Index) and followed up for more than 12 months and evaluate the complications at Tishreen University Hospital, Lattakia, Syria.

Results:

57 patients underwent total hip arthroplasty (26M,31F) with mean age 61.24 years.

40.3% of the studied research sample was within the age group of 60-69 years old.

33.3% of the studied research sample was in the overweight category according to the body mass index.

The posterior surgical approach was used in 68.8% of the studied research sample.

There was a significant increase in the mean values of WOMAC index one year after surgery.

There is a decrease in WOMAC values with increasing age, and an increase in the body mass index (BMI).

The most common complications were bleeding and the need for blood transfusion 84.2%, followed by limb-length discrepancy (LLD) 15.85 ,infection 5.8%, fracture 3.5%.

Recommendations and Suggestions:

We recommend using sementless components in total hip arthroplasty, and reserve the use of cement components for patients of advanced age, less active patients, and cases of severe osteoporosis.

We encourage patients to lose weight before and after surgery to improve clinical and functional outcomes.

Comparison of the efficacy of microneedling in the combination with platelet-rich plasma versus microneedling alone in treatment of striae distensae

Rida Shamayleh, Abdullah Alkhayer, Jamal Khaddam — Sun, 16 Feb 2025 00:00:00 +0000

Background: Striae distensae is considered one of the most common popular aesthetic problem especially among younger women. There are many therapeutic options for management, but no consistently effective modality is available yet.

Aim: The purpose of this study was to evaluate the efficacy of combination of microneedling and platelet-rich plasma (PRP) versus microneedling alone in treatment of striae distensae.

Materials and Methods: This was a randomized clinical trial (prospective) conducted for the period one year (2022-2023) in the clinic of dermatology at Tishreen University Hospital in Lattakia. The study included 19 patients with striae distensae who received treatment with microneedling alone and 19 patients who treated with microneedling and platelet-rich plasma(PRP), and final outcome was compared between two methods.

Results: Out of 38 patients, 8 patients (21.1%%) were male and 30 patients (78.9%) were female, with mean age of the patients was 29.34±7.4 years. Striae alba represented the most frequent type of striae (73.7%) and the most affected parts of body were abdomen (31.6%), flank (18.4%) and popliteal fossa (15.8%). There were no significant differences between two groups regarding of demographic and clinical characteristics(p>0.05). Good response occurred in 47.9% of the patients in combination group versus 26.3% in microneedling group, p: 0.03. There was significant difference between two groups regarding of satisfaction, in which 63.2% of the patients in combination group were highly satisfied versus 47.3% in microneedling group, p:0.01. In addition to, there was no association between improvement and the following variables: gender, age, Fitzpatrick skin type, type of striae, and its location (p>0.05).

Conclusion: The current study showed that microneedling with platelet-rich plasma appears to be effective in treating striae distensae.

Risk Factors of Perinatal Asphyxia in the Newborns at Tishreen University Hospital, Latakia

rahaf saleh — Sun, 16 Feb 2025 00:00:00 +0000

Background: Perinatal Asphyxia is one of the major contributors to neonatal morbidity and mortality in developing countries with an incidence rate of 1.5/1000 live births. It is the third most common cause of neonatal death. Several studies reported that there is a predisposing risk factor to asphyxia either before or at birth.

Objective: To identify the various causes that result in asphyxia among neonates at Tishreen University Hospital in Latakia.

Methods: The current study is an observational-analytical case-control study carried out in the period 2022 and 2023 in the Neonatal Intensive Care Unit of Tishreen University Hospital in Latakia. Only those neonates who had an Apgar score at 5 minutes less than 7 were included in the case group, while neonates who had an Apgar score of 7 or more than 7 were included in the control group. Data collection was done through a study-specific questionnaire and detail clinical history of the mother and neonate. All data were entered and analyzed using SPSS_25.

Results: Fifty-six neonates in total were prospectively divided into case and control groups. Multivariate analysis in this series identified the following as risk factors for perinatal asphyxia: meconium stained amniotic fluid, ( p=0.0001, 95% CI 2.2-8.9, RR 4.1); preterm rupture of membranes, (p=0.0001, 95%CI 1.3-10.7, RR 2.9); obstructed labor with vaginal delivery, (p=0.0001, 95%CI 1.4-9.5, RR 2.2).

Conclusion: Factors that include meconium stained amniotic fluid, preterm rupture of membranes, and obstructed labour with a vaginal delivery include some of the risk factors associated with perinatal asphyxia. Knowing these factors is an important step in taking early preventive measures, improving the quality of perinatal care, and optimal preparation for high-risk births.

Development of a 3D QSAR Model for the Prediction of HDAC2 Inhibitory Activity

Majd Mohamed, Faten Alchab — Sun, 16 Feb 2025 00:00:00 +0000

Histone Deacetylase 2 (HDAC2) plays an important role in various dangerous disease pathologies such as cancer, and was recently shown to be a desirable target for selective inhibition, thus multiple studies were conducted in an effort to develop potent selective HDAC2 inhibitors. This study focuses on developing a 3D QSAR model using a modified CoMSIA approach, in order to better determine inhibitory activity of novel compounds, while also providing a model to guide further inhibitor design and optimization. The models were generated using 168 carefully selected inhibitors from the literature, and were thereafter evaluated and validated through multiple parameters to determine the model with the best predictivity. The best generated model was then studied to identify important compound physiochemical properties that significantly affect inhibitory activity against HDAC2, and it was found that the presence of large bulky groups at the active site rim, together with an aromatic ring within the hydrophobic channel, enhance HDAC2 inhibitory activity.

The relationship between blood transfusion and atrial fibrillation in patients undergoing coronary artery bypass surgery

Fadi Jabbour — Sun, 16 Feb 2025 00:00:00 +0000

Abstract: New-onset atrial fibrillation after cardiac surgery contributes to increased morbidity, length of hospital stay, and resource utilization. Although many aspects of atrial fibrillation after cardiac surgery have been elucidated, the mechanism by which cardiac surgery predisposes patients to atrial fibrillation has remained unknown. Recent evidence supports the idea that blood transfusion enhances the inflammatory response, thereby increasing the incidence of postoperative atrial fibrillation.

Objectives: To determine the association of perioperative blood transfusion with atrial fibrillation, thus allowing strategies to be developed to reduce the incidence of this complication.

Patients and Methods: The study included 69 patients who underwent isolated coronary artery bypass grafting during 2023. The males percentage was 75.4% and females 24.6%. Patients were divided into two groups: Group 1 received blood units and Group 2 did not receive any blood units. Blood was transfused when hematocrit values fell in less than 26%, then the two groups were compared in terms of the occurrence of atrial fibrillation.

Results: CABG surgery was performed using cardio-polmunary bypass for 59 patients (85.5%) and on beating heart for 10 patients (14.5%). Blood was transfused for 56 patients (81.2%), while the number of patients who did not need blood transfusion was 13 (18.8%). 12 patients developed Atrial fibrillation in Group 1 and 2 in Group 2 with (P value >0.05).

Conclusions: Blood transfusion does not affect the incidence of atrial fibrillation after coronary artery bypass surgery.

Analytical Study of Percutaneous Ultrasound-guided Biopsies of Solid Pancreatic Lesions

Ali Resheh, Hassan Zaizafon, Rana Essa — Sun, 16 Feb 2025 00:00:00 +0000

Background: solid pancreatic lesions are important clinical problem in terms of the difficulty of establishing the correct diagnosis (benign or malignant), the high mortality rate associated with malignant lesions. This paper presents a descriptive analytical study of ultrasound-guided percutaneous biopsies in terms of histopathological results, complications, and some factors affecting of obtaining a clear qualitative diagnosis.

Methods: the study include 10 patients diagnosed with solid pancreatic lesions who underwent percutaneous biopsy from patients attending Tishreen University Hospital from July 2023 to July 2024.

Results: the histopathological results of biopsies were as follows: (7) cases of adenocarcinoma (70%), one case of metastases of well-differentiated tumor, one case of fibrosis with non-specific inflammation and one case with a result: (No malignancy in the studied sample). As for complication, there is one case of intraperitoneal hemorrhage (10%). The rate of obtaining a clear specific diagnosis was (80%) and the rate of non-specific diagnosis was (20%). The group with clear diagnosis had an older mean age (57.5 years) and a larger lesion size (mean maximum diameter 5.8 cm).

Conclusion: the study shows the importance of ultrasound –guided percutaneous biopsy as an effective method to obtain a clear qualitative diagnosis of solid pancreatic lesions, with a major complication rate (10%) and no biopsy-related deaths. We encourage further studies about this method as an effective method with short procedure time, low cost and low major complication rate.