The Prognostic Value of Pre-treatment Serum Lactate Dehydrogenase Levels in Acute Leukemia
Abstract
Objective: Leukemia is a globally increasing disease. Due to the reliance of tumor cells on anaerobic glucose metabolism for energy consumption, serum LDH levels are elevated. This has prompted us to study the prognostic significance of this enzyme to search for a specific, easily analyzable, and cost-effective marker.
Methods: The study included 105 participants: 75 newly diagnosed patients with acute leukemia (40 with acute myeloid leukemia and 35 with acute lymphoblastic leukemia) and 30 healthy individuals. LDH levels were measured using spectrophotometric assay with a Mindray device.
The patient samples were divided into three groups according to serum LDH levels: Group A had LDH levels lower than twice the normal value, Group B had LDH levels between twice and five times the normal value, and Group C had LDH levels greater than five times the normal value.
Results: The Overall survival and Progression-free survival rates were statistically higher in the group with lower LDH levels. There was a significant difference observed among the three patient groups divided according to LDH levels, with overall survival and progression-free survival rates of 93.8% and 68.6%, respectively, in Group A.
Conclusions: Pre-treatment serum LDH levels is an important predictive marker in leukemia patients, with high LDH levels indicating poor prognosis and lower survival rates. LDH can be depended on as a routine, cost-effective, and easily analyzable test.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.