دراسة تأثير نوعية السواغات الداخلة بتركيب المراهم الماصة للماء على تحرر ديكلوفيناك الصوديوم ( In vitro release system)
Abstract
تمت مقارنة معدل التحرر (Release Rate ) لمادة ديكلوفيناك الصوديوم باستخدام طريقة الديلزة من خلال استخدام غشاء سيللوزي يحوي المادة الفعالة ضمن وعاء بيشر من الماء المقطر محاط بحمام مائي.
ذلك من خلال استخدام 4 أنماط من المراهم الدسمة المحبة للماء ومقارنتها بالمرهم الشاهد
( مرهم كاره للماء) وهي:
A- الشاهد ويحوي الفازلين وزيت البارفبن
B– بارفين صلب +شمع النحل + غول سيتيلي + فازلين
C- لانولين مائي + فازلين
D– غول سيتيلي + لانولين + فازلين
E– شمع استحلابي + وزيت البارافين + فازلين
كان تركيز المادة الفعالة (Sodium Diclofenac ) 1% في كافة المراهم المدروسة.
بينت النتائج أن تحرر المادة الفعالة (Sodium Diclofenac ) كان أفضل ما يمكن بالعينةE
(الشمع اللاستحلابي) حيث بلغ تركيزها 0.084 mg/ml بعد ساعتين من بداية عملية التحرر ( In Vitro), بالمقابل انخفض تركيزها إلى أدنى مستوى في العينة الشاهد حيث بلغ 0.028 mg/ml . في حين بلغ تركيز المادة الفعالة في العينات B,C & D ) ) القيم: ( 0.043 ,C= 0.048 & D= 0.067mg/ml B=) وذلك بعد ساعتين من بداية عملية التحرر.
The release rate of sodium diclofenac has been studied in vitro dialysis system. The substance was suspended in a cellulosic bag into shaked and thermostatic water.
4 hydrophilic ointments were compared to control treatment (non-hydrophilic ointment).The Excipients in different ointments were:
A- Control Treatment contains Vaseline +Vaseline oil
B- Solid Paraffin + Bee Wax + Acetyl Alcohol + Vaseline
C- Hydrous Lanoline +Vaseline
D- Acetyl Alcohol + Vaseline + Lanoline
E- Wax Anionic Emulsifying+ Liquid Paraffin + Vaseline
The drug concentration was 1% in all treatments. The release rates of the drug were: 0.028,0.043,0.048,0.067,0.084mg/ml/2h. For the treatments A, B, C, D & E, successively. Drug releasing was higher in treatment E(0.084mg/ml/2h.), whereas this releasing was lower in treatment A–Control (0.028 mg/ml/2h.).
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