Impact of Storage Time and Temperature on Routine Coagulation Tests Results
Abstract
Introduction: Prothrombin time (PT) and activated paratial thromboplastin time (APTT) are routine coagulation tests used to assess pathological alterations of the coagulation system and monitoring anticoagulant therapy, therefor we report the effect of storage duration and temperature on prothrombin time and activated partial thromboplastin time.
Methods: We measured prothrombin time and activated paratial thromboplastin time in 105 plasma samples immediately after blood collection (basline) and after (4, 6, 24) hours storage at room temperature and 4°c. The mean percentage changes of greater than 10% were considered clinically relevant.
Result: The mean percentange changes for prothrombin time at both room temperature and 4°c after (4, 6, 24) hours were <10%. The mean percentage changes for activated paratial thromboplastin time at room temperature and 4°c after (4, 6) hours were <10%, but following 24 hours at room temperature and 4°c were >10%.
Conclusion: Plasma samples stored at room temperature and 4°c for 24 hours are acceptable for prothrombin time, Plasma samples stored at room temperature and 4°c for 6 hours are acceptable for activated paratial thromboplastin time.
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