OxLDL Is a Possible Marker for Increased Risk of Acute Coronary Syndromes

Authors

  • Dima Albardan Tishreen University
  • Afraa Zrieki Tishreen University
  • Muhammad Imad Khayat Tishreen University

Abstract

Objective: The aim of this study was to evaluate the usefulness of circulating oxidized low-density lipoprotein (OxLDL) as a risk marker of coronary artery disease (CAD) expressed in acute coronary syndromes (ACS) in comparison to low-density lipoprotein (LDL).

Methods: A total of 78 subjects were included: 60 patients with angiographically proven acute coronary syndromes divided into acute myocardial infarction group (AMI, n=30) and unstable angina group (UA, n=30) and 18 subjects without clinical evidence of coronary artery disease served as controls. OxLDL levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA). LDL levels were measured using enzymatic method.

Results: Plasma levels of OxLDL were significantly higher in each disease group than in control (p<0.001). The highest OxLDL levels were associated with the presence of hypertension and/or diabetes. OxLDL levels were correlated strongly with LDL levels in controls but weakly in ACS patients. The sensitivity and specificity for diagnosing ACS were 93% and 89% respectively for OxLDL versus 77% and 72% for LDL.

Conclusion: Circulating OxLDL is a better biomarker than LDL for discriminating between patients with ACS and healthy subjects. High levels of OxLDL could be a promising risk marker for coronary artery disease (CAD).

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Published

2022-09-07

How to Cite

1.
Albardan D, Zrieki A, Khayat MI. OxLDL Is a Possible Marker for Increased Risk of Acute Coronary Syndromes. Tuj-hlth [Internet]. 2022Sep.7 [cited 2024Apr.25];44(4):379-88. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/12775

Issue

Vol. 44 No. 4 (2022): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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