Analytical study to raise the sensitivity of sodium analysis using Flame Photometer method and its application on pharmaceutical preparation samples available in local market
Abstract
The type of linear relationship was studied between the concentrations of a standard solutions Ci of the element sodium and the intensity of the release for each of them in order to ensure that there is a correlation between them and thus evaluate the type of linear relationship. The effect of the counting of positive and negative ions and the type of medium on the signal intensity of this element was studied in order to find the optimal conditions for its determination by flame spectroscopy and thus determining it in realistic samples with high accuracy and high analysis sensitivity.
The results that were reached showed that there is an excellent linear relationship between the intensity of the release and the concentrations of this element, and this was confirmed by the value of the correlation coefficient R2 = 0.99 for the resulting standard curve.
It was observed that there was a positive effect of the chlorine ion Cl- on the intensity of emission of sodium, reaching a maximum of 15.8% at a concentration of 500 µg/ml, and the sulfate ion SO42- recorded a negative effect on the intensity of emission of sodium, where the percentage of decrease in the intensity of emission of sodium was 23% at a concentration of 500 µg/ml . The increase in the intensity of the release was 23% in a medium of hydrochloric acid with a concentration ranging between 0.05-0.5 N, and the effect of both nitric acid and acetic acid was weak.
The results also indicated a significant increase in the intensity of emission, reaching 37.1% at a concentration of 1500 µg/ml of calcium ion, When applying the optimal conditions, the sensitivity of the analysis in some pharmaceutical preparations was raised by 33% and a return or refund was obtained by 134%. The results of this study indicated that a detection limit of 0.29 µg/ml was reached, in comparison with the results of the study conducted without applying the optimal conditions.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series
Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal for Research and Scientific Studies - Health Sciences Series . The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal for Research and Scientific Studies - Health Sciences Series Publisher
journal uses a CC BY-NC-SA license which mean
You are free to:
- Share — copy and redistribute the material in any medium or format
- Adapt — remix, transform, and build upon the material
- The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
