Encapsulation of curcumin and diclofenac mixture with sodium alginate and chitosan and evaluation of the encapsulation efficiency

Authors

  • Riham Moalla Tishreen University
  • Muhammad Maarouf Tishreen University
  • Tareq Arraj Tishreen University
  • Wissam Zam Tartous university

Abstract

Curcumin synergizes with diclofenac to achieve a dose-related anti-inflammatory effect. Curcumin has an activity similar to that of diclofenac, allowing for reduction in side effects. Curcumin inhibits enzymes in the digestive system that destroy diclofenac, which increases the bioavailability of diclofenac, micro capsules of a mixture of curcumin and diclofenac were prepared using polymeric coatings such as sodium alginate with different concentrations and chitosan with specific concentrations in combination with sodium alginate of constant concentration after adding it to a calcium chloride solution.

The encapsulation efficiency when using sodium with a concentration of (3.5%), and calcium chloride with concentration of (2.5%), was 89.5% for curcumin and 98.3% for diclofenac. As for chitosan with sodium alginate at concentrations (0.5 to 3.5) %, the encapsulation rate for curcumin was 85.9% and for diclofenac was 87.5%, as the research results confirm that It is possible to adopt this method in encapsulation of a mixture of curcumin and diclofenac because it is fast, accurate, and has very good encapsulation efficiency.

Downloads

Published

2024-12-22

How to Cite

1.
معلا ر, محمد معروف, طارق عراج, وسام زم. Encapsulation of curcumin and diclofenac mixture with sodium alginate and chitosan and evaluation of the encapsulation efficiency. TUJ-BA [Internet]. 2024Dec.22 [cited 2025Jan.22];46(4):41-56. Available from: https://journal.tishreen.edu.sy/index.php/bassnc/article/view/17735

Issue

Vol. 46 No. 4 (2024): Tishreen University Journal of Research and Scientific Studies - Basic Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to the Tishreen University Journal -Basic Sciences Series  

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in Tishreen University Journal -Basic Sciences Series .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of Tishreen University Journal -Basic Sciences Series   Publisher

 

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.