Comparison of the efficacy of Inula viscose leaves extract with metronidazole against Giardia lamblia cysts: an experimental study

Authors

  • Amal Dayoub Tishreen University
  • Rim Salame Tishreen University
  • Samoual AL-Hakeem Tishreen University

Abstract

This study aimed to determine the effectiveness of Inula viscosa (L.) in comparison with metronidazole to eliminate the cysts of Giardia lamblia, as it is one of the most common plants in our local environment.

Infection due to the protozoa giardia is one of the most common parasitic infections in the world. Millions of people across the world acquire this infection each year. The most common clinical symptoms of giardiasis include abdominal pain, bloating diarrhea, indigestion, epigastric pain, nausea, vomiting and fatty foul-smelling stools.

Using known Drugs to treat giardiasis causes certain side effects, such as unpleasant taste in the mouth, gastrointestinal discomfort, nausea, headache and leukopenia. Considering the widespread nature of giardiasis infection, it is essential to identify anti-parasitic herbal drugs to eliminate cystic and trophozoite types of this disease.

The results of the laboratory study showed that the ethanolic extract of Inula viscose leaves is highly effective in eliminating giardia cysts. The percentage of dead cysts was rated 58%, for 3 hours of incubation, while this percentage of metronidazole was 38% Thus, Inula viscose has nearly twice the efficacy of the selective drug metronidazole at tested concentration.

Author Biographies

Amal Dayoub, Tishreen University

Professor in The Environmental Prevention

Rim Salame, Tishreen University

PHD in Phytochemistry, Pharmacy

Samoual AL-Hakeem, Tishreen University

Master student in The Environmental Prevention Department, Higher Institute for Environmental Research

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Published

2022-03-31

How to Cite

ديوب أ. ., سلامة ر. ., & الحكيم ا. . . (2022). Comparison of the efficacy of Inula viscose leaves extract with metronidazole against Giardia lamblia cysts: an experimental study. Tishreen University Journal -Biological Sciences Series, 44(1), 209–220. Retrieved from https://journal.tishreen.edu.sy/index.php/bioscnc/article/view/12095

Issue

Vol. 44 No. 1 (2022): Tishreen University Journal for Research and Scientific Studies - Biological Sciences Series

Section

Master student researches

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