A Comparative study of changes of some blood Parameters on complete blood count in smokers and non-smokers
Abstract
Tobacco cigarette smoking is one of causes of cardiovascular diseases , including coronary artery disease(CAD) , myocardial infarction(MI) , and stroke . It has been proven that the occurrence of these disorders in smokers is caused by abnormalities at Hemodynamic disorder in blood rheology ,infection and inflammation , oxidative stress , and alterations of antithrombotic and fibrinolysis system . however , the accurate of mechanisms of these disorders resulted from smoking cigarettes are still unknown. Therefore, the present study aims to assess the extent of adverse effects of cigarette smoking on three components of the complete blood count (CBC) test: Red Blood Cells (RBC), Hemoglobin(Hb) and Hematocrit(HTC). Moreover, the study investigates the relationship between smokers age and effects of smoking , effects of smoking amount (number of cigarettes smoked per day) on those three studied parameters. 355 subjects participated in this study including males and females with age over 17 years old Blood samples were taken from the participants and divided in two groups, 50 blood samples from nonsmoker participants and 305 from smoker participants. Blood sampling and (CBC) test were conducted using MEDONIC device COANTUS device at Tishreen University Hospital. The results of this research showed that the smokers had significantly higher levels of (RBC) and (Hb) and (HTC) comparing by nonsmokers (p≤0.05). Additionally, the results showed significant relation between the smoking amount and the extent of its effects on the studied components.
يعد تدخين السجائر احد الأسباب الرئيسة المسببة لأمراض القلب والأوعية الدموية بما في ذلك أمراض الشريان التاجي واحتشاء العضلة القلبية والسكتة الدماغية , ثبت أن حدوث هذه الاضطرابات لدى المدخنين ناتج عن خلل في جريان الدم والشدة التأكسدية واضطراب نظام التخثر وانحلال الفيبرين إلا ان الآليات الدقيقة لحدوث هذه الاضطرابات نتيجة تدخين السجائر لا تزال غير معروفة تماما لذلك تهدف هذه الدراسة إلى تقييم مدى الآثار السلبية لتدخين السجائر على ثلاثة معالم في اختبار تعداد الدم الكامل CBC)) وهي: عدد الكريات الحمراء و تركيز خضاب الدم ونسبة الهيماتوكريت وإيضاح العلاقة بين العمر وتأثير التدخين على المعالم المدروسة من جهة ,ومن جهة أخرى ودراسة العلاقة بين كمية التدخين (عدد السجائر في اليوم الواحد) على المعالم المدروسة. شملت الدراسة 355 عينة دموية مأخوذة من ذكور ونساء تجاوزت أعمارهم ال 17 عام وزعت العينات الدموية إلى مجموعتين 50 عينة دموية من غير المدخنين و 305 من المدخنين تم سحب الدم وإجراء اختبار ال(CBC) باستخدام جهازي MEDONUC , COANTUS في مشفى تشرين الجامعي أظهرت النتائج وجود ارتفاع معنوي في عدد الكريات الحمراء وتركيز خضاب الدم ونسبة الهيماتوكريت لدى مجموعة المدخنين بالقياس مع غير المدخنين P≤0.05 إضافة لوجود ارتباط معنوي بين عمر المدخن وتأثير كمية التدخين على المعالم المدروسة.
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