The role of immunohistochemistry P53 ,Ki-67, Bcl-2 In colorectal carcinoma prognosis

Authors

  • Issa Ahmed Tishreen University
  • Ali Dawood Tishreen University
  • Rina Saleh Tishreen University

Abstract

BACKGROUND: The incidence of colorectal cancer is rising over time, as it is the most common cause of cancer deaths after lung cancer. And the survival rate of 5 years is weak.

METHODS: We investigated the following IHC status p53, Ki-67, Bcl-2 in 80 colorectal cancer cases distributed over the years 2017-2019 from Tishreen University Hospital reviewers. The relationship of IHC prevalence to prognostic factors: age, tumor size, stage, grade, histological pattern, and presence of distant or lymph metastases. The cross-sectional statistical study was completed by using the SPSS program.

RESULTS: the tumor size in half of the cases >5 cm, 60% of the tumors were on the left side, metastases appeared in the lymph nodes in 53.75% of the cases, 10% of the patients suffered from distant metastases upon diagnosis, the results of IHC staining are as follows p53 (positive 48.75%), Bcl-2 (positive 55%) and severe positive Ki-67, 26.25%.

CONCLUSION: The presence of strong positivity Ki-67, P53 indicates an increase in
aggressive biological behavior, which calls for effective aggressive treatment with these
tumors to improve the prognosis.Bcl2 high expression correlated with good prognosis in CRC

Author Biographies

Issa Ahmed, Tishreen University

Professor - Department of Pathological Anatomy - College of Human Medicine

Ali Dawood, Tishreen University

Assistant Professor - Department of Pathological Anatomy - College of Human Medicine

Rina Saleh, Tishreen University

Postgraduate student (Master) - Department of Pathological Anatomy at the College of
Human Medicine

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Published

2021-05-31

How to Cite

1.
أحمد ع, داود ع, صالح ر. The role of immunohistochemistry P53 ,Ki-67, Bcl-2 In colorectal carcinoma prognosis. Tuj-hlth [Internet]. 2021May31 [cited 2024Apr.27];43(2). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10605

Issue

Vol. 43 No. 2 (2021): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

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