Efficacy of Intralesional Vitamin D3 in the Treatment of Recalcitrant Common and Plantar Warts


  • Foz Hassan Tishreen University
  • Nada Sahyouni Tishreen University


Background: Recalcitrant  warts represent a therapeutic challenge, with often disappointing response and high recurrence rates. Lately, treatment based on stimulating the cell-mediated immunity against HPV Virus has gained momentum.

Vitamin D3 Receptors are found in keratinocytes and on immune system cells . 

Vitamin D3 has a role in Regulating epidermal cell proliferation, differentiation, and apoptosis. It also modulates the immune response by regulating cytokines, and Anti Microbial Peptides production.

Patients and methods : forty patients with recalcitrant warts were included in the study.

Vitamin D3  (1 mL, 300,000 IU/mL) was injected into the base of the warts after Lidocaine  (0.5 mL, 20 mg/mL) injection. One wart, the greatest in diameter, was injected per session, in every clinically infected part . The sessions were at 2-week intervals until resolution of the injected wart or for a maximum of 4 treatments. Patients were followed up for 2 months after the last injection to evaluate complete Response.

Results: 29 patients (72,5%) showed complete clearance of both injected and non-injected warts. 11 patients (27,5%) didn’t show complete clearance of those 2 patients showed partial response by clearance of only the injected warts, whereas  9 patients showed no response.

Conclusion : Vitamin D3 is an effective, safe, and inexpensive method to treat recalcitrant common and palmoplantar warts.

Author Biographies

Foz Hassan, Tishreen University

Professor of Dermatology, Department of Dermatology

Nada Sahyouni, Tishreen University

Postgraduate Student, Department of Dermatology



How to Cite

حسن ف, صهيوني ن. Efficacy of Intralesional Vitamin D3 in the Treatment of Recalcitrant Common and Plantar Warts. Tuj-hlth [Internet]. 2021Jul.5 [cited 2024Jun.23];43(3). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10636

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