Efficacy of Intralesional Vitamin D3 in the Treatment of Recalcitrant Common and Plantar Warts

Authors

  • Foz Hassan Tishreen University
  • Nada Sahyouni Tishreen University

Abstract

Background: Recalcitrant  warts represent a therapeutic challenge, with often disappointing response and high recurrence rates. Lately, treatment based on stimulating the cell-mediated immunity against HPV Virus has gained momentum.

Vitamin D3 Receptors are found in keratinocytes and on immune system cells . 

Vitamin D3 has a role in Regulating epidermal cell proliferation, differentiation, and apoptosis. It also modulates the immune response by regulating cytokines, and Anti Microbial Peptides production.

Patients and methods : forty patients with recalcitrant warts were included in the study.

Vitamin D3  (1 mL, 300,000 IU/mL) was injected into the base of the warts after Lidocaine  (0.5 mL, 20 mg/mL) injection. One wart, the greatest in diameter, was injected per session, in every clinically infected part . The sessions were at 2-week intervals until resolution of the injected wart or for a maximum of 4 treatments. Patients were followed up for 2 months after the last injection to evaluate complete Response.

Results: 29 patients (72,5%) showed complete clearance of both injected and non-injected warts. 11 patients (27,5%) didn’t show complete clearance of those 2 patients showed partial response by clearance of only the injected warts, whereas  9 patients showed no response.

Conclusion : Vitamin D3 is an effective, safe, and inexpensive method to treat recalcitrant common and palmoplantar warts.

Author Biographies

Foz Hassan, Tishreen University

Professor of Dermatology, Department of Dermatology

Nada Sahyouni, Tishreen University

Postgraduate Student, Department of Dermatology

Downloads

Published

2021-07-05

How to Cite

1.
حسن ف, صهيوني ن. Efficacy of Intralesional Vitamin D3 in the Treatment of Recalcitrant Common and Plantar Warts. Tuj-hlth [Internet]. 2021Jul.5 [cited 2024Dec.26];43(3). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/10636

Issue

Vol. 43 No. 3 (2021): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)

1 2 > >>