Dexamethasone in bronchiolitis

Authors

  • Lina Mansour Tishreen University

Abstract

Aims of study: To determine  the role of dexamethasone in the treatment of infant who are less than  2 years , and have the first episode of    bronchiolitis

Materials and Methods: infant who had been admitted to the hospital for an initial episode of wheezing ( 206 infants between 3 month and  2 years) , we randomly divided in two groups:

Group (1): who they have been treated by dexamethasone ( intra-venous ) (1mg/kg/day) with bronchodilators ( inhaled ventolin)  (0.03mg /kg in 3ml of normal saline ).

Group (2): who they had been treated with only inhaled ventolin (0.03mg/kg in 3ml of normal salin) .

We assessed the respiratory disease and the response to the treatment  in two groups every 12 hours with : the rate of respiratory , severity of accessory muscle use  and wheezing score and pulse oximetry in room air.and resumption of normal feeding , for 4 days . we used ( RDAI) Respiratory disease assessment instrument  and ( RACS) Respiratory assessment change score , in assessment the infant .

We excluded infants who were younger than 3 month , who required admission to the intensive care unit, or who had a history of congenital heart disease , mechanical ventilation .

We used a proportional hazards model for our survival  analysis . and square kai test .

Results : 206 infants admitted with episode of bronchiolitis , the rate of response to intravenous dexamethasone and inhaled ventolin (103 infants) was obviously higher when was comparaed with the rate of response to the inhaled ventolin only ( 87,37% vs 13.6% ) .

The duration of hospilatation with the infants who were treated with dexamethasone and ventolin was shorter than the infants who were treated with ventolin only , it was (3-5 ) days (81.55%) in group (1) vs (5-7) days (47.57%) in group (2) .

Conclusions: There were differences between the infants who were treated with  dexamethasone and  ventolin and who treated with  ventolin only  , the use of dexamethasone (iv) accelerate the response to the treatment and reduce the duration of hospitalization in infants who have bronchiolitis . 

 

Author Biography

Lina Mansour, Tishreen University

Masters- Faculty of Human Medicine

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Published

2021-10-28

How to Cite

1.
منصور ل. Dexamethasone in bronchiolitis. Tuj-hlth [Internet]. 2021Oct.28 [cited 2024Nov.24];43(5). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/11006

Issue

Vol. 43 No. 5 (2021): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

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Articles

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