Study of Ki67 proliferation index association with clinico-pathological features of non-Hodgkin’s lymphoma at Tishreen University Hospital

Authors

  • Azza Ibraheem tishreen university
  • Firas Hussein Tishreen University
  • Samer Akel Tishreen University

Abstract

Purpose : we aim to study the Correlation between the Proliferative index Ki67 and clinical variables (staging ,B symptoms ), demographic variables (age , sex) , histologic variables (subtype of NHL , anatomic site , extra nodal involvement , bone marrow involvement ) in NHL patients .

Method: the study sample consisted of 90 patients who were admitted and treated at the Cancer Treatment Center in Tishreen University Hospital between 2015 and 2020 , we did a retrospective study on the files of NHL lymphoma patients who achieved the inclusion criteria and studied the previous variables and Ki67

Results: the value of Ki67 was between 3% and 100% with a median value approximates   50,2%±26,2% . we divided patients into two groups depending on the value of Ki67 : ≥45% and <45% , the we compared the previous variables with this two groups . the difference of age and sex between the two Ki67 value groups were not statically (P-value :0,311/0,449  in respect ) or clinically significant , so as the staging according to the Ann Arbor staging system ( P-value:0,207) . we noticed that  there was a  significant association to the subtypes of NHL , the value of Ki67≥45% was associated with DLBCL ، Burkit ، High Grade B Cell . whereas the value of Ki67<45% were associated basically  with FL ، SLL ، Small B Cell ، T Cell Rich B Cell with astatically importance ( p-value : 0,006) . lastly the value of Ki67≥45% was associated with high levels of extra nodal sites (P-value: 0,001)  , B symptoms (P-value : 0,020 )   , bone marrow involvement  (P-value: 0,001)   and high levels of LDH (P-value:0,001) .

Conclusion : our study showed that there was significant association between high values of Ki67 (≥45%) and the more aggressive subtypes of NHL and also with positive  extra nodal sites ,B symptoms and bone marrow involvement .

Published

2022-09-07

How to Cite

1.
ابراهيم ع, فراس حسين, سامر عاقل. Study of Ki67 proliferation index association with clinico-pathological features of non-Hodgkin’s lymphoma at Tishreen University Hospital. Tuj-hlth [Internet]. 2022Sep.7 [cited 2024Jul.18];44(4):223-44. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/12738

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