Assessment of cardiovascular risk depending on lipid profile in women with Polycycstic Ovary Syndrome
Abstract
Introduction: Polycycstic Ovary Syndrome contribute to metabolic problems including dyslipidemia that is a key risk factor can lead to an early development to CVD.
Aim: This research aimed to screen for dyslipidemia in PCOS patients in order to investigate the risk of atherogenicity and cardiometabolic health in PCOS patients, through calculating the Atherogenic index of plasma (AIP) which is a novel marker to predict the risk of atherosclerosis and coronary heart disease.
Materials and Methods: This Observational Descriptive study included 59 PCOS patients and 20 controls, aged 18-38 years old attending the Gynecology Clinic of Tishreen Hospital; The patients’ lipid profile was titrated; and AIP was defined as the logarithm of the ratio of the concentration of Triglyceride (TG) To HDL-C.
Results: Prevalence of dyslipidemia was 32.2% of total patients group, we also found that low HDL-C was the most dyslipidemia pattern in our research reached 25.24% of total patients, on average women with PCOS were lower HDL-C levels of 20 mg/dl compared to controls, while higher LDL-C, TG, Total Cholesterol levels 23.58 mg/dl, mg/dl,36.09 mg/dl and 21.71mg/dl respectively. the Atherogenic index of plasma was higher of 0.21 in 6.8% that is associated with high cardiovascular risk.
Conclusion: This study showed that women with PCOS had atherogenic lipoprotein profile characterized by lower HDL-C, increased LDL-C, TG, Total Cholesterol and necessarily increased AIP, so that it is important to investigate for dyslipidemia in PCOS Patients which may be a risk factor for developing cardiovascular complication later on.
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