Studying the relationship between the gene expression level of the HOTAIR molecule and HER2 receptor in breast cancer

Authors

  • Ansam Abdullah Tishreen University
  • Faisal redwan Tishreen University
  • Nader abedullaa Tishreen University
  • Eyad alshatti Damascus University

Abstract

Objective: The molecular classification of breast cancer contributes to following targeted treatment lines, and HER2 receptors constitute one of the important characteristics in the therapeutic decision, and within the framework of the search for molecular markers that contribute to understanding the pathological mechanisms of breast cancer with the aim of developing accurate and specific treatment lines. A number of interventional experimental studies have clarified the role of Long non-coding RNA (LncRNA) molecules in the pathogenesis of breast cancer. The HOTAIR molecule was studied as a tumor-stimulating LncRNA molecule through its control of gene expression at several molecular levels. This molecule also had a role in the occurrence of therapeutic resistance in Breast cancer. Our study aims to measure the level of gene expression of the HOTAIR molecule in the serum of patients and study its relationship with HER2 receptors.materials and methods: An assay was conducted for the level of gene expression of the HOTAIR molecule in the plasma of 30 patients, by performing a reverse transcription reaction (qPCR). Gene expression was evaluated using the Levack equation, and HER2 receptors were identified on tissue biopsies in the pathology department. Then a statistical analysis of the results was performed.Results: The results of the study showed that there were significant differences (P<0.05) between the level of HOTAIR gene expression and HER2 receptor positivity.

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Published

2024-06-06

How to Cite

1.
عبدالله أ, فيصل رضوان, نادر عبد الله, إياد الشطي. Studying the relationship between the gene expression level of the HOTAIR molecule and HER2 receptor in breast cancer. Tuj-hlth [Internet]. 2024Jun.6 [cited 2024Nov.24];46(2):183-90. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/16902

Issue

Vol. 46 No. 2 (2024): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

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Articles

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