Measurement of copper serum level in Acute Myocardial Infarction patients and comparing with CKmb and Troponin

Authors

  • Nagham ALALOUNI Tishreen university
  • Mohammad Imad Khayyat Tishreen University
  • Bassem Maarouf Tishreen University

Abstract

Background: Proving the presence of a significant increase in serum copper values in acute myocardial infarction patients and finding a relationship between high levels of copper and cardiac marker CKmb enables us to distinguish high risk acute myocardial infarction patients who need more stringent control of cardiac risk factors , intensive treatment , and close medical follow up .

Identifying the group of high risk patients enables us to make the decision to perform invasive interventions faster . .

Objectives: the main objective: Measuring the level of serum copper and CKmb in patients with acute myocardial infarction compared with normal people .

Secondary objective: Study of the relationship between the level of copper in serum and the level of CKmb in patients with acute myocardial infarction .

Materials and methods: Statistical study ( Case – Control ) , The research sample included 50 patients who were admitted to the emergency department at Tishreen University Hospital in Latakia within 12 hours of the appearance of clinical symptoms that indicate decreased myocardial ischemia during the time period between April 2022 – 2023 . The investigators included the research inclusion criteria .

A sample of 25 patients attending the hospital for other reasons was taken during the same time period , with the aim of comparing the serum copper level with them and studying the correlation between the serum copper level and CKmb .

The diagnosis of acute myocardial infarction was made by the doctors of the cardiology department at Tishreen University Hospital based on the clinical examination and symptoms , in addition to the results of the electrocardiogram and laboratory test values . Copper was also calibrated in the central laboratory at Tishreen University Hospital using the semi – automated HUMAN device using the colorimetric method , As for CKmb the calibration was done on automated devices in the hospital using the kinetic method .

Results: Serum copper values are higher in patients with acute myocardial infarction compared to normal people.

The value of serum copper in patients with acute myocardial infarction increases as the value of the cardiac marker CKmb increases

Conclusion: Measuring the level of serum copper in patients with acute myocardial infarction to help assess the severity of the injury and thus help speed up appropriate treatment procedures and prevent the occurrence of serious complications.

Further studies into the possibility of using copper chelators to reduce signs or slow the progression of ischemic heart disease .

Downloads

Published

2024-04-08

How to Cite

1.
العلوني ن, محمد عماد خياط, باسم معروف. Measurement of copper serum level in Acute Myocardial Infarction patients and comparing with CKmb and Troponin. Tuj-hlth [Internet]. 2024Apr.8 [cited 2024May2];46(1):421-32. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/16877

Issue

Vol. 46 No. 1 (2024): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)