Role of superdisintegrants in enhancing dissolution rate of valsartan

Authors

  • Narjess Baabaa Tishreen University
  • Nisrin Kaddar Tishreen University
  • Nathalie Moussa Tishreen University

Abstract

Drug solubility and dissolution rate vitally affects its oral bioavailability. Unfortunately, most marketed drugs exhibit low solubility. Valsartan, an angiotensin II receptor blocker, and one of the most effective and commonly used anti-hypertension agents, suffers from low solubility and dissolution rate, and therefore low oral bioavailability. As such, enhancing its dissolution rate could prove very beneficial for the management of hypertension. This study made use of the superdisintegrants crospovidone and croscarmellose, which exhibit ameliorating properties such as wicking and swelling, in order to enhance the disintegration profile of valsartan capsule formulations, and in turn improve its dissolution rate. Seven formulations were prepared and subjected to various quality assessment tests, concluding with an in-vitro dissolution test to identify the optimal formulations.

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Published

2024-11-10

How to Cite

1.
Baabaa N, Nisrin Kaddar, Nathalie Moussa. Role of superdisintegrants in enhancing dissolution rate of valsartan. Tuj-hlth [Internet]. 2024Nov.10 [cited 2025Jan.26];46(4):279-92. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/17642

Issue

Vol. 46 No. 4 (2024): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

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