Role of superdisintegrants in enhancing dissolution rate of valsartan

Authors

  • Narjess Baabaa Tishreen University
  • Nisrin Kaddar Tishreen University
  • Nathalie Moussa Tishreen University

Abstract

Drug solubility and dissolution rate vitally affects its oral bioavailability. Unfortunately, most marketed drugs exhibit low solubility. Valsartan, an angiotensin II receptor blocker, and one of the most effective and commonly used anti-hypertension agents, suffers from low solubility and dissolution rate, and therefore low oral bioavailability. As such, enhancing its dissolution rate could prove very beneficial for the management of hypertension. This study made use of the superdisintegrants crospovidone and croscarmellose, which exhibit ameliorating properties such as wicking and swelling, in order to enhance the disintegration profile of valsartan capsule formulations, and in turn improve its dissolution rate. Seven formulations were prepared and subjected to various quality assessment tests, concluding with an in-vitro dissolution test to identify the optimal formulations.

Downloads

Published

2024-11-10

How to Cite

1.
Baabaa N, Nisrin Kaddar, Nathalie Moussa. Role of superdisintegrants in enhancing dissolution rate of valsartan. Tuj-hlth [Internet]. 2024Nov.10 [cited 2024Nov.24];46(4):279-92. Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/17642

Issue

Vol. 46 No. 4 (2024): Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

Section

Master student researches

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The authors retain the copyright and grant the right to publish in the magazine for the first time with the transfer of the commercial right to Tishreen University Journal for Research and Scientific Studies - Health Sciences Series

 Under a CC BY- NC-SA 04 license that allows others to share the work with of the work's authorship and initial publication in this journal. Authors can use a copy of their articles in their scientific activity, and on their scientific websites, provided that the place of publication is indicted in  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series   .  The Readers have the right to send, print and subscribe to the initial version of the article, and the title of  Tishreen University Journal for Research and Scientific Studies - Health Sciences Series  Publisher

journal uses a CC BY-NC-SA license which mean

You are free to:

  • Adapt — remix, transform, and build upon the material
  •  
  • The licensor cannot revoke these freedoms as long as you follow the license terms.

 

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  • NonCommercial — You may not use the material for commercial purposes.
  • ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
  • No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.