القيمة التشخيصية للدراسة الخلوية (Cytology) في دراسة تضيقات الشجرة الصفراوية

Authors

  • حسان زيزفون
  • رنا عيسى
  • سليمان الخليل

Abstract

أُجري هذا البحث لدراسة دور الدراسة الخلوية (cytology) بالفرشاة في تحديد سبب التضيق ضمن الشجرة الصفراوية . حيث أنّ الفرشاة تُعتبر تقنيةً ذاتَ قيمةٍ كبيرةٍ لتوفير العينات الخلوية أثناء إجراء تصوير الطرق الصفراوية و المعثكلية التنظيري بالطريق الراجع (ERCP) لمرضى التضيق الصفراوي . شملت الدراسة 34 مريضاً مع تضيق صفراوي , و تم إجراء ERCP لجميع المرضى و أخذت عينات للدراسة الخلوية باستخدام الفرشاة . و خلال مدة الدراسة التي بلغت عاماً , تم وضع التشخيص النهائي لجميع هؤلاء المرضى بمقاربة منهجية (سريرية , شعاعية , مخبرية , نسيجية بخزعات جراحية ) . و دُرست حساسية و نوعية الفرشاة لتشخيص التضيق الخبيث و بلغت حساسيتها 57.1% , نوعية 100% , قيمة تنبؤية إيجابية 100% , قيمة تنبؤية سلبية 76.9 % , و دقة تشخيصية 82%. النتيجة : إن الدراسة الخلوية بالفرشاة تملك نوعيةً عاليةً جداً و لكن حساسيةً متوسطة لتشخيص التضيق الخبيث و مع ذلك فيهي ذات فائدةٍ تشخيصيةٍ عاليةٍ للتمييز بين الأسباب الخبيثة و الحميدة للتضيق الصفراوي . This research is designed to study the diagnostic yield of brush cytology for biliary strictures. Brush cytology technique is of a great value to provide cytological samples during ERCP for patients with biliary strictures . The study included 34 patients with biliary stricture, ERCP was performed to all patients and cellular samples were taken using a brush for cytology . During the study period (one year) , the final diagnosis was made using a systematic approach based on clinical, radiological, laboratory or histopathological diagnosis . Sensitivity and specificity of brush cytology were studied . The sensitivity of biliary brushing was 57.1% , specificity was 100%, positive predictive value was 100% , negative predictive value was 76.9% and accuracy was 82% . Conclusions: Brush cytology has a very high specificity but an intermediate sensitivity for the diagnosis of malignant biliary strictures . Despite that , brush cytology is of a high diagnostic utility to distinguish between malignant and benign causes of biliary strictures .

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Published

2017-10-15

How to Cite

1.
زيزفون ح, عيسى ر, الخليل س. القيمة التشخيصية للدراسة الخلوية (Cytology) في دراسة تضيقات الشجرة الصفراوية. Tuj-hlth [Internet]. 2017Oct.15 [cited 2024Nov.24];38(6). Available from: https://journal.tishreen.edu.sy/index.php/hlthscnc/article/view/3231

Issue

Vol. 38 No. 6 (2016): العلوم الصحية

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