دراسة تأثير الميتفورمين على البدانة واضطراب الطمث عند مريضات PCOS
Abstract
إن الهدف من هذه الدراسة هو معرفة تأثير تطبيق دواء الميتفورمين على عينة من مريضات لديهن متلازمة المبيض متعدد الكيسات ( polycystic ovary syndrome ) خاصة فيما يتعلق بالبدانة وتواتر الطمث , ثم مقارنة التغيرات السريرية والمخبرية قبل وبعد العلاج . وأخيراً النظر في إمكانية اعتبار الميتفورمين كواحد من الأدوية الحديثة في علاج المتلازمة .
تضمنت العينة ( 50 ) مريضة , تم انتقاء المريضات بعد تشخيص المتلازمة سريرياً ومخبرياً وبالأمواج فوق الصوت .
لقد حقق الدواء فائدة معقولة في زيادة تواتر الطمث وفي تحسين قيمة مشعر كتلة الجسم BMI ونسبة الخصر/الورك W/H .
تبين لنا من خلال البحث أن الميتفورمين مفيد لمريضات PCOS مع خلل تحمل السكر سيما البدينات عن تحسين عمل الأنسولين على مستوى الخلية دون التأثير على مستوى الأنسولين .
The aim of this research is to study the effects of Metformin administration on a sample of patients with polycystic ovary syndrome (PCOS), especially regarding obesity and menstrual disorders. This study also aims to compare clinical and laboratory changes before and after treatment . Finally, we consider the possibility of using Metformin as a new drug for the treatment of this syndrome. The sample included (50) patients diagnosed with PCOS. This diagnosis was confirmed through clinical, laboratory, and ultra-sound examinations. Metformin produced a good result in increasing menstrual frequency and making the value of BMI and W/H close to being normal.
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