Evaluation the salivary zinc assay as a potential diagnostic tool in potential malignant lesions of oral cavity
Abstract
Salivary analysis, a non-invasive alternative to serum analysis, is an effective modality for diagnosis and for prognosis prediction of various diseases like oral cancer and even oral potentially malignant disorders. The aim of this study was to evaluate the level of zinc (Zn) in saliva of patients with oral leukoplakia (OL) and to compare the values with healthy controls. The study group comprised of15 clinically diagnosed and histopathologically confirmed cases of OL and 15 healthy controls matched in age and gender. The data were assessed statistically using SPSS.
It was observed a slight decrease in OL patients(151.73 ±11.37 )compared with controls (156.13±10.12).However ,it was statistically insignificant (P>0.05).
Further research is needed in this line in patients with oral potential malignant disorders with higher sample size in order to correlate habit and diet pattern which may affect the Zn status.
تحليل اللعاب هو بديل غير باضع للنسج كما أنه وسيلة فعالة لتشخيص والتنبؤ بإنذار العديد من الأمراض مثل سرطان الفم والآفات محتملة الخباثة .هدف هذه الدراسة تقييم مستويات الزنك في اللعاب لدى مرضى الطلاوة الفموية ومقارنة هذه القيم مع المجموعة الضابطة . مجموعة الدراسة ضمت 15 حالة طلاوة مشخصة سريرياً ونسيجياً و15 من الضوابط المطابقة في العمر والجنس . المعطيات قيمت إحصائياً باستخدام برنامج التحليل الإحصائي SPSS.كان هناك انخفاض في مستويات الزنك 151.73 ±11.37 عند مرضى الطلاوة مقارنة بالمجموعة الضابطة التي أظهرت مستويات أعلى 156.13±10.12ولكن هذا الانخفاض ليس ذو دلالة إحصائياً حيث (P>0.05).هناك حاجة إلى مزيد من البحث في هذا المجال في المرضى الذين يعانون من آفات فموية محتملة الخباثة بحجم عينة أكبر بهدف ربط نمط التغذية و العادات التي يمكن أن تؤثر على حالة الزنك .
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